AXL RECEPTOR TYROSINE KINASE STIMULATED BY THE VITAMIN-K-DEPENDENT PROTEIN ENCODED BY GROWTH-ARREST-SPECIFIC GENE-6
AXL RECEPTOR TYROSINE KINASE STIMULATED BY THE VITAMIN-K-DEPENDENT PROTEIN ENCODED BY GROWTH-ARREST-SPECIFIC GENE-6
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DOI：
10.1038/373623a0
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发表时间：
1995-02-16
期刊：
影响因子：
64.8
通讯作者：
YAMANE, HK
中科院分区：
文献类型：
--
作者：
VARNUM, BC;YOUNG, C;YAMANE, HK
Axl受体酪氨酸激酶被鉴定为一种由转化基因编码的蛋白质，该转化基因通过DNA介导的NIH 3 T3细胞转化而得自原代人髓性白血病细胞（1-3）。Axl是一个相关受体家族的创始成员，该家族包括Eyk（4）和c-Mer（5），Eyk（4）由最初被描述为逆转录病毒转化基因的鸡原癌基因编码，c-Mer（5）由在肿瘤性B-和T-细胞系中表达的人原癌基因编码。Axl的转化活性表明该受体可以驱动细胞增殖。Axl在非转化细胞和组织中的功能是未知的，但可能涉及响应于适当的信号（即激活受体的配体）刺激细胞增殖。我们在此报告了Axl刺激因子的纯化，并将其鉴定为生长停滞特异性基因6的产物（参考文献6）。据我们所知，这是Axl受体家族配体的首次描述。
THE Axl receptor tyrosine kinase was identified as a protein encoded by a transforming gene from primary human myeloid leukaemia cells by DNA-mediated transformation of NIH 3T3 cells(1-3). Axl is the founding member of a family of related receptors that includes Eyk(4), encoded by a chicken proto-oncogene originally described as a retroviral transforming gene, and c-Mer(5), encoded by a human proto-oncogene expressed in neoplastic B- and T-cell lines. The transforming activity of Axl demonstrates that the receptor can drive cellular proliferation. The function of Axl in non-transformed cells and tissues is unknown, but may involve the stimulation of cell proliferation in response to an appropriate signal, namely a ligand that activates the receptor. We report here the purification of an Axl stimulatory factor, and its identification as the product of growth-arrest-specific gene 6 (ref. 6). This is, to our knowledge, the first description of a ligand for the Axl family of receptors.