Genetic Predisposition to High Blood Pressure and Lifestyle Factors Associations With Midlife Blood Pressure Levels and Cardiovascular Events
Genetic Predisposition to High Blood Pressure and Lifestyle Factors Associations With Midlife Blood Pressure Levels and Cardiovascular Events
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DOI：
10.1161/circulationaha.117.030898
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发表时间：
2018-02-13
期刊：
影响因子：
37.8
通讯作者：
Tzoulaki, Ioanna
中科院分区：
文献类型：
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作者：
Pazoki, Raha;Dehghan, Abbas;Tzoulaki, Ioanna
背景：高血压（BP）是心血管疾病（CVD）的主要危险因素，心血管疾病是全球死亡的主要原因。遗传和生活方式风险因素都有助于血压水平升高。我们的目的是调查生活方式因素在多大程度上可以抵消不良BP遗传特征的影响及其对CVD风险的影响。我们通过使用来自英国生物银行研究的277005名既往无CVD的个体中的314个已发表的BP位点构建了高血压的遗传风险评分，该研究是一项前瞻性队列研究，年龄在40至69岁之间，中位随访时间为6.11年。我们根据他们的生活方式因素对参与者进行评分，包括体重指数，健康饮食，久坐的生活方式，饮酒，吸烟和招募时测量的尿钠排泄水平。我们分别用线性回归和考克斯回归模型检验了遗传风险三分位数和生活方式评分三分位数与血压水平和心血管事件的关系。
BACKGROUND: High blood pressure (BP) is a major risk factor for cardiovascular diseases (CVDs), the leading cause of mortality worldwide. Both heritable and lifestyle risk factors contribute to elevated BP levels. We aimed to investigate the extent to which lifestyle factors could offset the effect of an adverse BP genetic profile and its effect on CVD risk.METHODS: We constructed a genetic risk score for high BP by using 314 published BP loci in 277 005 individuals without previous CVD from the UK Biobank study, a prospective cohort of individuals aged 40 to 69 years, with a median of 6.11 years of follow-up. We scored participants according to their lifestyle factors including body mass index, healthy diet, sedentary lifestyle, alcohol consumption, smoking, and urinary sodium excretion levels measured at recruitment. We examined the association between tertiles of genetic risk and tertiles of lifestyle score with BP levels and incident CVD by using linear regression and Cox regression models, respectively.RESULTS: Healthy lifestyle score was strongly associated with BP (P