Inhibin-B as a test of ovarian reserve for infertile women.
Inhibin-B as a test of ovarian reserve for infertile women.
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抑制素 B 作为不孕女性卵巢储备的测试。
DOI：
10.1093/humrep/14.11.2818
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发表时间：
1999
期刊：
影响因子：
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通讯作者：
Soules,MR
中科院分区：
文献类型：
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作者：
Corson,SL;Gutmann,J;Batzer,FR;Wallace,H;Klein,N;Soules,MR
该研究的目的是比较标准的克罗米芬柠檬酸盐挑战试验与同样在周期第3天和第10天获得的白细胞介素-B血清浓度，作为一组106名卵巢功能受损风险妇女的妊娠阴性预测因子。平均随访时间为8.25个月，95例患者记录了30例妊娠（加上一项生化检查）。周期第3天和第10天的抑制素B浓度仅相互相关，与血清雌二醇、促卵泡激素（FSH）和/或妊娠率无关。在所有患者中，34.5%（10/29）的患者在周期第3天的B-B值≥45 pg/ml，31.8%（21/66）的值<45 pg/ml。当FSH >11 mIU/ml时，妊娠率为13.6%，而当FSH ≤9 mIU/ml时，妊娠率为38.4%（P= 0.03）。这项研究再次证实了克罗米芬激发试验作为卵巢储备功能指标的有效性，但未能发现阿糖胞苷-B试验的临床价值。
The objective of the study was to compare a standard clomiphene citrate challenge test with inhibin-B serum concentrations also obtained on cycle days 3 and 10 as a negative predictor of pregnancy in a group of 106 women at risk for compromised ovarian function. Mean duration of follow-up was 8.25 months in 95 patients with 30 pregnancies recorded (plus one biochemical). Inhibin-B concentrations on cycle days 3 and 10 were correlated only with each other and not with serum oestradiol, follicle stimulating hormone (FSH) and/or pregnancy rates. Pregnancy occurred in 34.5% (10/29) of all patients with inhibin-B values ≥45 pg/ml on cycle day 3 and in 31.8% (21/66) of those with values <45 pg/ml. For FSH >11 mIU/ml on either day, pregnancy rate was 13.6% versus 38.4% for FSH of ≤9 mIU/ml (P= 0.03). This study reconfirmed the usefulness of a clomiphene citrate challenge test as an indication of ovarian reserve but failed to find clinical value for inhibin-B testing.