In vivo detection of cucurbit[6]uril, a hyperpolarized xenon contrast agent for a xenon magnetic resonance imaging biosensor.
In vivo detection of cucurbit[6]uril, a hyperpolarized xenon contrast agent for a xenon magnetic resonance imaging biosensor.
复制标题
体内检测cucultit [6]尿路，尿液是Xenon磁共振成像生物传感器的超极化XENON对比剂。
DOI：
10.1038/srep41027
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发表时间：
2017-01-20
影响因子：
4.6
通讯作者：
Albert MS
中科院分区：
文献类型：
--
作者：
Hane FT;Li T;Smylie P;Pellizzari RM;Plata JA;DeBoef B;Albert MS
超极化气体化学交换饱和转移（hyperest）磁共振（MR）技术有可能提高超极化氙-129 MRI造影剂的灵敏度。信号增强是通过选择性地使笼状分子内的氙去极化来实现的，在交换时，这种去极化减少了溶解相池中的信号。在这里，我们展示了在活体大鼠的脉管系统内检测葫芦b[6]脲（CB6）造影剂。我们的工作可以作为使用HyperCEST技术作为分子成像方式的垫脚石。
The Hyperpolarized gas Chemical Exchange Saturation Transfer (HyperCEST) Magnetic Resonance (MR) technique has the potential to increase the sensitivity of a hyperpolarized xenon-129 MRI contrast agent. Signal enhancement is accomplished by selectively depolarizing the xenon within a cage molecule which, upon exchange, reduces the signal in the dissolved phase pool. Herein we demonstrate the in vivo detection of the cucurbit[6]uril (CB6) contrast agent within the vasculature of a living rat. Our work may be used as a stepping stone towards using the HyperCEST technique as a molecular imaging modality.