Kinetics of subcutaneous NPH insulin in diabetics
Kinetics of subcutaneous NPH insulin in diabetics
复制标题
糖尿病患者皮下注射 NPH 胰岛素的动力学
DOI：
10.1038/clpt.1982.66
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发表时间：
1982
影响因子：
6.7
通讯作者：
J. Bojsen
中科院分区：
文献类型：
--
作者：
K. Kølendorf;J. Bojsen
在新诊断的胰岛素依赖型糖尿病患者中研究了皮下注射NPH胰岛素的动力学。使用生物遥测技术，将小型盖革-缪勒探测器应用于皮肤表面，125 I-NPH胰岛素从皮下组织中的消失呈单指数，平均半衰期为6.6 ± 3.3（SD）h。提出了一个模型，以比较皮下125 I-NPH胰岛素的消失率和从实际血浆胰岛素浓度测量值得出的计算的血浆外观胰岛素曲线，假设为一室模型和一级动力学根据外部测量值和血浆胰岛素浓度计算的吸收和出现时间曲线下面积相同。标记胰岛素的血药浓度与吸收量呈显著正相关（r = 0.8782，P < 0.001），降糖效果与每小时吸收胰岛素百分率呈显著正相关（r = 0.7659，P < 0.001）。我们的研究结果表明，碘标记胰岛素的消失率是皮下组织胰岛素吸收的相关生物学表达，是定量测定血液中胰岛素浓度的可靠的无创方法。
Kinetics of subcutaneous NPH insulin were studied in newly diagnosed insulin‐dependent diabetics. Using a biotelemetric technique with small Geiger‐Müller detectors applied to the skin surface, the disappearance of 125I‐NPH insulin from subcutis was mono exponential with a mean half‐life of 6.6 ± 3.3(SD) hr. A model is presented to compare the disappearance rates of subcutaneous 125I‐NPH insulin and the calculated plasma appearance insulin curve derived from the actual plasma insulin concentration measurements, assuming a one‐compartment model and first‐order kinetics. Areas under the absorption‐ and appearance‐time curves calculated from external measurements and from plasma insulin concentrations were identical. There was a strong correlation between plasma concentrations and absorbed amounts of labeled insulin (r = 0.8782, P < 0.001), as there was between the blood glucose–lowering effects and percent absorbed insulin per hour (r = 0.7659, P < 0.001). Our results indicate that the disappearance rate of iodine‐labeled insulin was a relevant biological expression of insulin absorption from subcutis and a reliable noninvasive method of quantitative determination of insulin concentration in blood.