Evaluation of an early exercise intervention after thoracotomy for non-small cell lung cancer (NSCLC), effects on quality of life, muscle strength and exercise tolerance: Randomised controlled trial
Evaluation of an early exercise intervention after thoracotomy for non-small cell lung cancer (NSCLC), effects on quality of life, muscle strength and exercise tolerance: Randomised controlled trial
复制标题
DOI：
10.1016/j.lungcan.2010.04.025
复制
发表时间：
2011-02-01
期刊：
影响因子：
5.3
通讯作者：
Garrod, Rachel
中科院分区：
文献类型：
--
作者：
Arbane, Gill;Tropman, David;Garrod, Rachel
运动耐量恶化和生活质量（QoL）受损是肺叶切除术的常见后果。本研究评估了肺切除术后额外的运动和力量训练对生活质量、运动耐量和肌肉力量的影响。53例（28例男性）因肺癌接受开胸手术的患者，平均年龄64（32-82）岁;平均包年（SD）31.9（26.8）; BMI 25.6（4.2）; FEV 1 2.0（0.7）1，被随机分配至对照组（常规护理）或干预组（每日两次训练加常规护理）。出院后，干预组接受每月一次的家访和每周一次的电话随访，对照组接受每月一次的电话随访，持续12周。术前、术后5天和12周的评估包括使用磁刺激的四头肌力量、6分钟步行距离（6 MWD）和QoL-EORTC-QLQ-LC 13。QoL在12周内无变化;术后5天6 MWD与术前相比显著恶化，活性组和对照组的平均差异（SD）分别为-131.6（101.8）m和128.0（90.7）m（两组间p = 0.89），两组均在12周时恢复至术前水平。5天住院期间，对照组股四头肌力量下降8.3（11.3）kg，而干预组增加4.0（21.2）kg（两组间p = 0.04）。开胸术后的力量训练成功地防止了对照组的股四头肌力量下降，但是对6 MWD或QoL没有影响。无论是否提供额外支持，6 MWD均在12周时恢复至术前水平。皇冠版权所有（C）2010由爱思唯尔爱尔兰有限公司出版。保留所有权利。
Deterioration in exercise tolerance and impairment in quality of life (QoL) are common consequences of lobectomy. This study evaluates additional exercise and strength training after lung resection on QoL, exercise tolerance and muscle strength. Fifty-three (28 male) patients attending thoracotomy for lung cancer, mean age, range 64 (32-82) years; mean pack years (SD) 31.9 (26.8); BMI 25.6 (4.2); FEV1 2.0 (0.7)1 were randomised to control (usual care) or intervention (twice daily training plus usual care). After discharge the intervention group received monthly home visits and weekly telephone calls, the control group received monthly telephone calls up to 12 weeks. Assessment pre-operatively, 5 day and 12 weeks post-operatively consisted of quadriceps strength using magnetic stimulation, 6 Minute Walking Distance (6MWD) and QoL-EORTC-QLQ-LC13. QoL was unchanged over 12 weeks; 6MWD showed significant deterioration at 5 days post-operatively compared with pre-operatively, mean difference (SD)-131.6 (101.8) m and 128.0(90.7) m in active and control groups respectively (p = 0.89 between groups) which returned to pre-operative levels by 12 weeks in both groups. Quadriceps strength over the 5 day in-patient period showed a decrease of 8.3 (11.3) kg in the control group compared to increase of 4.0 (21.2) kg in the intervention group (p = 0.04 between groups). Strength training after thoracotomy successfully prevented the fall in quadriceps strength seen in controls, however, there was no effect on 6MWD or QoL. 6MWD returned to pre-operative levels by 12 weeks regardless of additional support offered. Crown Copyright (C) 2010 Published by Elsevier Ireland Ltd. All rights reserved.