Recent progress in asymmetric two-center catalysis
Recent progress in asymmetric two-center catalysis
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DOI：
10.1039/b203495f
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发表时间：
2002-01-01
影响因子：
4.9
通讯作者：
Funabashi, K
中科院分区：
文献类型：
--
作者：
Shibasaki, M;Kanai, M;Funabashi, K
介绍了两种不对称双中心催化剂--Lewis酸-Bronsted碱和Lewis酸-Lewis碱双功能络合物的研究进展。本综述的第一部分讨论了锌连接联苯二醇络合物在合成选择性直接催化不对称羟醛缩合反应和2-羟基苯乙酮衍生物的1，4-加成反应中的改进。在第二部分中，我们描述了在醛的不对称氰硅化反应中显示Lewis酸性和Lewis碱性的催化剂的发展，以及通过Reissert型反应和酮的氰硅化反应合成四取代碳的合理扩展。
Recent progress using two types of enantioselective two-center catalysts, Lewis acid-Bronsted base and Lewis acid-Lewis base bifunctional complexes, is described. The first part of this review discusses improvements in the syn-selective direct catalytic enantioselective aldol reaction and 1,4-addition reaction of a 2-hydroxyacetophenone derivative using a Zn-linked-BINOL complex. In the second part, we describe the development of catalysts displaying Lewis acidity and Lewis basicity in a catalytic enantioselective cyanosilylation of aldehydes and the logical extension to a tetrasubstituted carbon synthesis through a Reissert-type reaction and a cyanosilylation of ketones.