Bimanual motor deficits in older adults predicted by diffusion tensor imaging metrics of corpus callosum subregions
Bimanual motor deficits in older adults predicted by diffusion tensor imaging metrics of corpus callosum subregions
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DOI：
10.1007/s00429-013-0654-z
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发表时间：
2015-01-01
影响因子：
3.1
通讯作者：
Swinnen, Stephan P.
中科院分区：
文献类型：
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作者：
Serbruyns, L.;Gooijers, J.;Swinnen, Stephan P.
胼胝体（CC）的微结构组织中的与年龄相关的变化可以解释与正常老化相关的双手运动性能下降。我们使用扩散张量成像在年轻人（n = 33）和老年人（n = 33）调查的微结构组织的七个特定的CC亚区（前额叶，运动前区，初级运动，初级感觉，顶叶，颞叶和枕叶）。一组双手任务被用来评估双手运动功能的各个方面：普渡钉板测试，同时和交替的手指敲击，选择反应时间测试和复杂的视觉跟踪任务。老年人表现出与年龄相关的缺陷的双手运动性能的所有措施。在老年组的相关性分析表明，白色物质各向异性分数的CC枕区与双手精细操作技能（普渡钉板测试），而更好的表现在其他双手任务相关的更高的分数各向异性在更前面的运动前区，初级运动和初级感觉CC亚区。这种关联在年轻组中不太突出。我们的研究结果表明，分区域胼胝体纤维的结构变化可能占双手运动在正常老化的下降。
Age-related changes in the microstructural organization of the corpus callosum (CC) may explain declines in bimanual motor performance associated with normal aging. We used diffusion tensor imaging in young (n = 33) and older (n = 33) adults to investigate the microstructural organization of seven specific CC subregions (prefrontal, premotor, primary motor, primary sensory, parietal, temporal and occipital). A set of bimanual tasks was used to assess various aspects of bimanual motor functioning: the Purdue Pegboard test, simultaneous and alternating finger tapping, a choice reaction time test and a complex visuomotor tracking task. The older adults showed age-related deficits on all measures of bimanual motor performance. Correlation analyses within the older group showed that white matter fractional anisotropy of the CC occipital region was associated with bimanual fine manipulation skills (Purdue Pegboard test), whereas better performance on the other bimanual tasks was related to higher fractional anisotropy in the more anterior premotor, primary motor and primary sensory CC subregions. Such associations were less prominent in the younger group. Our findings suggest that structural alterations of subregional callosal fibers may account for bimanual motor declines in normal aging.