A new diagnostic index for sarcopenia and its association with short-term postoperative complications in patients undergoing surgery for colorectal cancer
A new diagnostic index for sarcopenia and its association with short-term postoperative complications in patients undergoing surgery for colorectal cancer
复制标题
肌肉减少症的新诊断指标及其与结直肠癌手术患者短期术后并发症的关系。
DOI：
10.1111/codi.14558
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发表时间：
2019-05-01
影响因子：
3.4
通讯作者：
Li, J.
中科院分区：
文献类型：
--
作者：
Yang, J.;Zhang, T.;Li, J.
肌肉减少症是结直肠癌（CRC）手术后预后的一个可靠指标。然而，没有血清标记物常规可用于估计骨骼肌质量（SMM）。本研究旨在描述一种新的肌少症指数（SI），血清肌酐（Scr）xcystatin C为基础的肾小球滤过率，并探讨其与根治性切除CRC. MethodConcrete术后短期并发症的相关性，回顾性确定了从2011年12月至2017年1月接受根治性切除CRC的患者。在L3计算机断层扫描图像上分析骨骼肌横截面积。受试者工作特征曲线分析显示，肌肉减少症的SI的截断点在男性中低于56.1，在女性中低于43.7。根据这些临界值将患者分为低SI组和高SI组。结果在417例患者中，SI与骨骼肌面积（SMA）呈较强的相关性（r= 0.537，P
AimSarcopenia is a robust prognostic indicator of outcomes after surgery for colorectal cancer (CRC). However, there are no serum markers routinely available for estimating skeletal muscle mass (SMM). The present study aimed to describe a new sarcopenia index (SI), serum creatinine (Scr)xcystatin C-based glomerular filtration rate, and investigate its association with short-term complications after curative resection of CRC.MethodConsecutive patients who underwent curative resection of CRC from December 2011 to January 2017 were retrospectively identified. Skeletal muscle cross-sectional area was analysed on L3 computed tomographic images. Receiver operating characteristic curve analysis showed that the cutoff points of SI for sarcopenia were below 56.1 in men and below 43.7 in women. Patients were classified into low and high SI groups in accordance with these cutoff values. The association between SI and body composition and the impact of preoperative SI on postoperative outcomes were analysed.ResultsAmong 417 patients, SI showed a stronger correlation with skeletal muscle area (SMA) (r=0.537, P