Structural requirement for the action of leukotriene B4 on the guinea-pig lung:importance of double bond geometry in the 6, 8, 10-triene unit.
Structural requirement for the action of leukotriene B4 on the guinea-pig lung:importance of double bond geometry in the 6, 8, 10-triene unit.
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白三烯 B4 对豚鼠肺作用的结构要求：6、8、10-三烯单元中双键几何形状的重要性。
DOI：
10.1016/0006-291x(81)91757-5
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发表时间：
1981
影响因子：
3.1
通讯作者：
E. Corey
中科院分区：
文献类型：
--
作者：
P. Sirois;S. Roy;P. Borgeat;S. Picard;E. Corey
本文比较了四种合成的5（S），12（R）-二羟基-6，8，10，14-二十碳四烯酸与天然的白三烯B 4（LTB 4）在豚鼠肺灌注和肺实质条中的作用。研究发现，具有6-顺式、8，10-反式三烯单元的合成LTB 4（图1）与天然LTB 4一样强大，既能收缩实质带，又能从灌注肺中释放前列腺素和血栓素，而其他三种异构体则没有活性。结果表明，LTB 4对肺的作用高度依赖于共轭三烯的几何构型。
The action of four synthetic 5 (S), 12 (R)-dihydroxy-6, 8, 10, 14-eicosatetraenoic acids has been compared to the action of natural leukotriene B 4 (LTB 4) in perfused guinea-pig lung and in the parenchymal strip preparations. Synthetic LTB 4 (Fig. 1) having the 6-cis, 8, 10-trans triene unit was found to be as powerful as natural LTB 4 both for contracting the parenchymal strip and for releasing prostaglandins and thromboxanes from the perfused lung while three other isomers were inactive. The results indicate that the action of LTB 4 on the lung is highly dependent on the geometry of the conjugated triene.