Modulation of neuronal activity in the nucleus raphe magnus by the 5-HT1-receptor agonist naratriptan in rat
Modulation of neuronal activity in the nucleus raphe magnus by the 5-HT1-receptor agonist naratriptan in rat
复制标题
DOI：
10.1016/s0304-3959(00)00405-x
复制
发表时间：
2001-02-15
期刊：
影响因子：
7.4
通讯作者：
Hu, JW
中科院分区：
文献类型：
--
作者：
Ellrich, J;Messlinger, K;Hu, JW
用细胞外记录法观察了5-HT_1受体激动剂那拉曲坦对大鼠中缝大核神经元的调制作用。静脉注射那拉曲普坦后，中缝大核的on-cells神经元活动减少，off-cells神经元活动增加。那拉曲普坦的调节作用与吗啡对中缝大核神经元的作用相似。这项研究的结果表明，那拉曲普坦的中枢作用，并可能指向内源性疼痛控制系统参与5-HT 1受体激动剂的抗伤害性作用。(C)2001年国际疼痛研究协会。由Elsevier Science B. V.出版，版权所有。
Modulatory effects of the new antimigraine drug naratriptan, a 5-HT1-recptor-agonist, on neurons of the nucleus raphe magnus were examined in rat by extracellular recordings. In the nucleus raphe magnus neuronal activity decreased in on-cells and increased in off-cells after intravenous administration of naratriptan. The modulatory effects of naratriptan were similar to the well-known effects of morphine on neurons in the nucleus raphe magnus. The results of this study suggest central actions of naratriptan and may point to an involvement of the endogenous pain control system in the antinociceptive ve effects of the 5-HT1-receptor-agonist. (C) 2001 International Association for the Study of Pain. Published by Elsevier Science B.V. All rights reserved.