The striopallidal pathway is involved in antiparkinsonian-like effects of the blockade of group I metabotropic glutamate receptors in rats
The striopallidal pathway is involved in antiparkinsonian-like effects of the blockade of group I metabotropic glutamate receptors in rats
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DOI：
10.1016/s0304-3940(03)00221-0
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发表时间：
2003-05
影响因子：
2.5
通讯作者：
K. Ossowska;J. Wardas;M. Pietraszek;J. Konieczny;S. Wolfarth
中科院分区：
文献类型：
--
作者：
K. Ossowska;J. Wardas;M. Pietraszek;J. Konieczny;S. Wolfarth
本研究的目的是研究I组代谢型谷氨酸受体（mGluRs）的阻断对氟哌啶醇诱导的僵住症和脑啡肽原mRNA在大鼠纹状体中表达的影响。双侧纹状体内注射I组mGluRs选择性拮抗剂AIDA（（RS）-1-aminodan-1，5-diarboxylic acid，3- 1,5 μg/0.5 μl）可抑制氟哌啶醇（0.5 mg/kg i. p.）诱导的僵住。重复纹状体内AIDA给药（3×15 μg/0.5 μl，间隔3 h）可抵消氟哌啶醇诱导的（3×1.5 mg/kg s.c.，间隔3 h）该结构中前脑啡肽mRNA表达增加。目前的研究表明，纹状体I组mGluRs的封锁可能会抑制帕金森氏症运动不能通过正常化的功能，striopallidal途径。
The aim of the study was to examine the influence of the blockade of group I metabotropic glutamate receptors (mGluRs) on the haloperidol-induced catalepsy and proenkephalin mRNA expression in the rat striatum. Bilateral, intrastriatal injection of AIDA ((RS)-1-aminoindan-1,5-dicarboxylic acid, 3–15 μg/0.5 μl), a selective antagonist of group I mGluRs, inhibited catalepsy induced by haloperidol (0.5 mg/kg i.p.). Repeated intrastriatal AIDA administrations (3×15 μg/0.5 μl, 3 h apart) counteracted the haloperidol-induced (3×1.5 mg/kg s.c., 3 h apart) increase in the proenkephalin mRNA expression in that structure. The present study indicates that the blockade of the striatal group I mGluRs may inhibit parkinsonian akinesia by normalizing the function of the striopallidal pathway.