Expression of cancer stem cell markers ALDH1 and Bmi1 in oral erythroplakia and the risk of oral cancer
Expression of cancer stem cell markers ALDH1 and Bmi1 in oral erythroplakia and the risk of oral cancer
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DOI：
10.1111/j.1600-0714.2012.01191.x
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发表时间：
2013-02-01
影响因子：
3.3
通讯作者：
Zhou, Zeng-Tong
中科院分区：
文献类型：
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作者：
Feng, Jin-Qiu;Xu, Zi-Yuan;Zhou, Zeng-Tong
背景：口腔红斑病（OE）是一种众所周知的侵袭性口腔癌前病变，极有可能发展为口腔癌，但其生物学行为很大程度上未知。本研究的目的是确定肿瘤干细胞标志物 ALDH1 和 Bmi1 在 OE 中的表达及其与 OE 恶性转化的相关性。方法：在一项回顾性病例对照研究中，采用免疫组织化学法测定 34 例 OE 患者样本中 ALDH1 和 Bmi1 的表达模式，其中包括未转化病变患者 (n=17) 和恶性转化病变患者 (n=17)。结果：34 例 OE 患者中，分别有 19 例（55.9%）和 20 例（58.8%）观察到 ALDH1 和 Bmi1 表达。多变量分析显示 ALDH1 表达与转化风险增加显着相关（P
Background: Oral erythroplakia (OE) is a notoriously aggressive oral pre-malignant lesion with a high tendency to oral cancer development, but its biological behavior is largely unknown. The objective of this study was to determine the expression of cancer stem cell markers ALDH1 and Bmi1 in OE and their correlation with malignant transformation of OE. Methods: In a retrospective casecontrol study, expression patterns of ALDH1 and Bmi1 were determined using immunohistochemistry in samples from 34 patients with OE, including patients with untransformed lesions (n=17) and patients with malignant transformed lesions (n=17). Results: ALDH1 and Bmi1 expression was observed in 19 (55.9%) and 20 (58.8%) of 34 patients with OE, respectively. Multivariate analysis revealed that ALDH1 expression was significantly associated with increased risk of transformation (P