Impact of linoleic acid intake on arachidonic acid formation and eicosanoid biosynthesis in humans
Impact of linoleic acid intake on arachidonic acid formation and eicosanoid biosynthesis in humans
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DOI：
10.1016/j.plefa.2008.09.007
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发表时间：
2008-09-01
影响因子：
3
通讯作者：
Wolfram, G.
中科院分区：
文献类型：
--
作者：
Adam, O.;Tesche, A.;Wolfram, G.
在6名健康女性中进行亚油酸（LA）的长链转化和类花生酸的形成，这些女性被给予6周不含花生四烯酸的液体配方饮食，但各持续2周，LA供应分别为0能量%（en%）、4 en%和20 en%。较高的LA摄入导致所研究的脂质中较高的LA百分比，但与液体配方饲料（LFD）相比，LDL和HDL的血浆胆固醇酯或磷脂酰胆碱中的LA含量并不高4和LFD 20。较高的摄入量的LA导致减少花生四烯酸，这是最突出的HDL磷脂酰胆碱。摄入LA后，由环氧合酶活性产生的类花生酸没有变化，而LFD 20可增加细胞色素P450依赖的tetranorprostanedioic酸的形成。结论：摄入4en %的LA似乎是一个可接受的摄入量，没有刺激类花生酸生物合成或氧化的迹象。(c)2008爱思唯尔有限公司保留所有权利。
Long-chain conversion of linoleic acid (LA) and eicosanoid formation was followed in 6 healthy females who were given for 6 weeks liquid formula diets which contained no arachidonic acid but, for 2 weeks each, a LA supply of 0 energy% (en%), 4 en%, and 20 en%, respectively.Results: higher LA intake resulted in higher LA percentages in investigated lipids, but not in higher amounts of LA present in plasma cholesterol esters or phosphatidylcholine of LDL and HDL comparing liquid formula diet (LFD) 4 and LFD 20. A higher intake of LA resulted in a decrease of arachidonic acid, which was most prominent in HDL phosphatidycholine. Eicosanoids derived from cyclo-oxygenase activity were unchanged by LA intake, while an increase of cytochrome P450-dependent tetranorprostanedioic acid formation was observed with LFD 20.Conclusion: LA intake of 4 en% appears to be a recommendable intake, without signs of stimulated eicosanoid biosynthesis or oxidation. (c) 2008 Elsevier Ltd. All rights reserved.