High intake of dairy during energy restriction does not affect energy balance or the intestinal microflora compared with low dairy intake in overweight individuals in a randomized controlled trial
High intake of dairy during energy restriction does not affect energy balance or the intestinal microflora compared with low dairy intake in overweight individuals in a randomized controlled trial
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在一项随机对照试验中，与超重个体的低乳制品摄入量相比，能量限制期间高乳制品摄入量不会影响能量平衡或肠道微生物区系
DOI：
10.1139/apnm-2017-0234
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发表时间：
2018-01-01
影响因子：
3.4
通讯作者：
Larsen, Lesli Hingstrup
中科院分区：
文献类型：
--
作者：
Bendtsen, Line Quist;Blaedel, Trine;Larsen, Lesli Hingstrup
在减肥过程中，乳制品钙被认为可以通过增加粪便脂肪排泄来加速体重和脂肪的减少。主要目的是调查在24周内，高乳制品能量限制饮食在体重、身体成分和粪便脂肪排泄方面是否优于低乳制品饮食。次要目标包括粪便能量和钙排泄、静息能量消耗、血压、脂质代谢和肠道微生物群。在一项随机平行干预研究中，11名男性和69名女性(体重指数30.6 +/- 0.3 kg/m；年龄（44岁以上/- 1岁）的参与者被分配到500千卡（2100千焦）不足的饮食中，这些饮食要么高（高钙：1500毫克钙/天），要么低（低钙：600毫克钙/天），持续24周。习惯性钙摄入量与1000毫克/天相似。24周内各组的体重减轻（HD: -6.6 +/- 1.3 kg, LD: -7.9 +/- 1.5 kg, P = 0.73）、脂肪质量减少（HD: -7.8% +/- 1.3%, LD: -8.5% +/- 1.1%, P = 0.76）、粪便脂肪排泄变化（HD: -0.57 +/- 0.76 g, LD: 0.46 +/- 0.70 g, P = 0.12）和微生物群组成相似。然而，与饮食组无关，总脂肪量减少与乳突杆菌的相对丰度呈正相关（P = 0.017）。在超过24周的时间里，高乳制品饮食并没有增加粪便脂肪，也没有加速超重和肥胖成年人的体重和脂肪量的减少，他们的习惯性钙摄入量接近1000毫克/天。然而，本研究表明，乳突杆菌参与了机体成分的改变。
During weight loss, dairy calcium is proposed to accelerate weight and fat-mass loss through increased fecal fat excretion. The primary objective was to investigate if a high-dairy energy-restricted diet is superior to low dairy in terms of changes in body weight, body composition, and fecal fat excretion over 24 weeks. Secondary objectives included fecal energy and calcium excretion, resting energy expenditure, blood pressure, lipid metabolism, and gut microbiota. In a randomized, parallelarm intervention study, 11 men and 69 women (body mass index, 30.6 +/- 0.3 kg/m(2); age, 44 +/- 1 years) were allocated to a 500-kcal (2100 kJ) -deficit diet that was either high (HD: 1500 mg calcium/day) or low (LD: 600 mg calcium/day) in dairy products for 24 weeks. Habitual calcium intake was similar to 1000 mg/day. Body weight loss (HD: -6.6 +/- 1.3 kg, LD: -7.9 +/- 1.5 kg, P = 0.73), fat-mass loss (HD: -7.8% +/- 1.3%, LD: -8.5% +/- 1.1%, P = 0.76), changes in fecal fat excretion (HD: -0.57 +/- 0.76 g, LD: 0.46 +/- 0.70 g, P = 0.12), and microbiota composition were similar for the groups over 24 weeks. However, total fat-mass loss was positively associated with relative abundance of Papillibacter (P = 0.017) independent of diet group. Consumption of a high-dairy diet did not increase fecal fat or accelerate weight and fat-mass loss beyond energy restriction over 24 weeks in overweight and obese adults with a habitual calcium intake of similar to 1000 mg/day. However, this study indicates that Papillibacter is involved in body compositional changes.