Rapid Determination of Enantiomeric Excess via NMR Spectroscopy: A Research-Informed Experiment
Rapid Determination of Enantiomeric Excess via NMR Spectroscopy: A Research-Informed Experiment
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DOI：
10.1021/acs.jchemed.6b00355
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发表时间：
2017-01-01
影响因子：
3
通讯作者：
Roper, Kimberley A.
中科院分区：
文献类型：
--
作者：
Fossey, John S.;Anslyn, Eric V.;Roper, Kimberley A.
描述了一个本科生化学实验，从主要的研究。实验利用手性超分子组装体通过H-1 NMR光谱测定对映体过量。本报告描述了实验交付给一组学生，并作为反馈的结果，从那些参与，提出了一个优化的协议。特别注意通过提供全面的教学支持材料以及技术指导来促进其他机构的快速采用，以支持实验。
An undergraduate chemistry experiment that draws from primary research is described. The experiment exploits chiral supramolecular assemblies for the determination of enantiomeric excess by H-1 NMR spectroscopy. This report describes the delivery of the experiment to a cohort of students, and as a result of feedback from those involved, an optimized protocol is presented. Particular care has been taken to facilitate ready adoption in other institutions by providing comprehensive teaching support materials as well as technical guidance-for supporting the experiment.