Pair bond formation is impaired by VPAC receptor antagonism in the socially monogamous zebra finch
Pair bond formation is impaired by VPAC receptor antagonism in the socially monogamous zebra finch
复制标题
DOI：
10.1016/j.bbr.2014.06.042
复制
发表时间：
2014-10-01
影响因子：
2.7
通讯作者：
Goodson, James L.
中科院分区：
文献类型：
--
作者：
Kingsbury, Marcy A.;Goodson, James L.
最近的各种数据表明，血管活性肠多肽（VIP）和VPAC受体（结合VIP，并在较小程度上，垂体腺苷酸环化酶激活肽）是重要的鸣禽的许多社会行为，包括分组和侵略，虽然VIP涉及这些行为在一个网站特定的方式。为了确定中央VPAC受体激活对社会行为的全球影响，我们在这里注入VPAC受体拮抗剂或车辆每天两次到侧脑室的殖民地安置的男性和女性斑胸草雀和量化的广泛的行为。攻击性行为没有改变脑室输液，符合已知的反对，网站特定的关系VIP神经支配的侵略。求偶和自我维持行为同样没有改变。然而，VPAC拮抗作用产生了显着的赤字对键合。拮抗剂受试者需要更长时间形成配对关系，并且相对于对照受试者配对的观察期显著更少（拮抗剂受试者的6个观察期中位值为1.5，对照受试者为4）。拮抗剂受试者在最终观察期配对的可能性也显著降低。基于已知的VPAC受体在雀类和其他脊椎动物中的分布，我们提出，VPAC受体可能介导通过各种大脑区域，已知是重要的伙伴偏好在田鼠，包括外侧隔，腹侧被盖区，腹侧苍白球和腹侧苍白球的建立对键合。(C)2014爱思唯尔有限公司版权所有。
A variety of recent data demonstrate that vasoactive intestinal polypeptide (VIP) and VPAC receptors (which bind VIP, and to a lesser extent, pituitary adenylatecyclase activating peptide) are important for numerous social behaviors in songbirds, including grouping and aggression, although VIP relates to these behaviors in a site-specific manner. In order to determine the global effects of central VPAC receptor activation on social behavior, we here infused a VPAC receptor antagonist or vehicle twice daily into the lateral ventricle of colony-housed male and female zebra finches and quantified a wide range of behaviors. Aggressive behaviors were not altered by ventricular infusions, consistent with known opposing, site-specific relationships of VIP innervation to aggression. Courtship and self-maintenance behaviors were likewise not altered. However, VPAC antagonism produced significant deficits in pair bonding. Antagonist subjects took longer to form a pair bond and were paired for significantly fewer observation sessions relative to control subjects (median 1.5 of 6 observation sessions for antagonist subjects versus 4 for control subjects). Antagonist subjects were also significantly less likely to be paired in the final observation session. Based on the known distribution of VPAC receptors in finches and other vertebrates, we propose that VPAC receptors may mediate pair bonding via a variety of brain areas that are known to be important for the establishment of partner preferences in voles, including the lateral septum, ventral tegmental area, nucleus accumbens and ventral pallidum. (C) 2014 Elsevier B.V. All rights reserved.