Breast Cancer in Latinas: A Focus on Intrinsic Subtypes Distribution.
Breast Cancer in Latinas: A Focus on Intrinsic Subtypes Distribution.
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DOI：
10.1158/1055-9965.epi-17-0420
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发表时间：
2018-01
期刊：
影响因子：
--
通讯作者：
Zabaleta J
中科院分区：
文献类型：
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作者：
Serrano-Gómez SJ;Fejerman L;Zabaleta J
乳腺癌是全世界女性中最常见的癌症。它被分为内在亚型，以不同的分子特征和预后为特征。不同内在亚型的患病率在不同人群中有所不同。基于雌激素受体（ER）、孕激素受体（PR）和人表皮生长因子受体2 （HER2）表达的免疫组织化学替代物已被广泛用于研究非西班牙裔白人和非洲裔美国人固有亚型的分布，但西班牙裔/拉丁裔女性的数据有限。同样，大多数分析基因表达谱的研究只包括欧洲血统的女性。本综述的重点是描述西班牙裔/拉丁裔妇女乳腺癌亚型分布的研究，并强调需要对这一人群进行更多的研究。
Breast cancer is the most frequent cancer in women worldwide. It is classified into intrinsic subtypes characterized by different molecular profiles and prognosis. The prevalence of the different intrinsic subtypes varies between population groups. Immunohistochemistry surrogates based on the expression of the estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) have been widely used to study the distribution of intrinsic subtypes in Non-Hispanic Whites and African Americans, but data is limited for Hispanic/Latina women. Similarly, most studies analyzing gene expression profiles only include women of European descent. The present review focuses on studies that describe the distribution of breast cancer subtypes in Hispanic/Latina women and highlights the need for more research in this population.