Large-scale search for genes on which positive selection may operate
Large-scale search for genes on which positive selection may operate
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DOI：
10.1093/oxfordjournals.molbev.a025629
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发表时间：
1996-05-01
影响因子：
10.7
通讯作者：
Gojobori, T
中科院分区：
文献类型：
--
作者：
Endo, T;Ikeo, K;Gojobori, T
我们对正选择可能作用的候选基因进行了系统性搜索，前提是当比较所研究基因的核苷酸序列时，对于这些基因，非同义取代的数量预计会大于同义取代的数量。通过从DDBJ、EMBL和GenBank DNA序列数据库中获得3，595组同源序列，我们发现17个基因组可以作为正选择可能操作的基因的候选者。因此，发现这些基因仅占迄今为止可获得的大量基因组的约0.5%。有趣的是，17个基因组中有9个是寄生虫或病毒的表面抗原。
We conducted a systematic search for the candidate genes on which positive selection may operate, on the premise that for such genes the number of nonsynonymous substitution is expected to be larger than that of synonymous substitutions when the nucleotide sequences of the genes under investigation are compared with each other. By obtaining 3,595 groups of homologous sequences from the DDBJ, EMBL, and GenBank DNA sequence databases, we found that 17 gene groups can be the candidates for the genes on which positive selection may operate. Thus, such genes are found to occupy only about 0.5% of the vast number of gene groups so far available. Interestingly enough, 9 out of the 17 gene groups were the surface antigens of parasites or viruses.