Pharmaceutical Applications of Microcalorimetry
Pharmaceutical Applications of Microcalorimetry
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DOI：
10.1023/a:1018957103417
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发表时间：
1994-05
影响因子：
3.7
通讯作者：
M. Koenigbauer
中科院分区：
文献类型：
--
作者：
M. Koenigbauer
本文综述了微量热法的基本原理和应用。微量热法在物理、化学和生物药物相互作用的研究中是有用的。本仪器的灵敏度约为0.1 µW。凭借这种高灵敏度，已经开发了其他应用，包括药物与食物，淋巴瘤细胞，微生物，血液，赋形剂和环糊精的相互作用。微量热法最近的一个应用是测量药物的降解速率。
General principles and applications of microcalorimetry are reviewed. Microcalorimetry is useful in the study of physical, chemical, and biological drug interactions. The sensitivity of the present instrumentation is approximately 0.1 µW. With this high sensitivity, additional applications have been developed, including the interactions of drugs with food, lymphoma cells, microorganisms, blood, excipients, and cyclodextrin. A recent application of microcalorimetry is the measurement of degradation rates of drugs.