Maternal chronic hepatitis B virus infection does not affect pregnancy outcomes in infertile patients receiving first in vitro fertilization treatment
Maternal chronic hepatitis B virus infection does not affect pregnancy outcomes in infertile patients receiving first in vitro fertilization treatment
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母亲慢性乙型肝炎病毒感染不影响首次接受体外受精治疗的不孕患者的妊娠结局
DOI：
10.1016/j.fertnstert.2019.03.039
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发表时间：
2019-08-01
影响因子：
6.7
通讯作者：
Zeng, Yong
中科院分区：
文献类型：
--
作者：
Wang, Linlin;Li, Longfei;Zeng, Yong
目的：评价母亲慢性B型肝炎病毒（HBV）感染是否影响首次体外受精（IVF）治疗的不孕患者的妊娠结局。设计：一项回顾性病例对照研究。设置：生育中心。患者：女性患者，包括8，550名不孕妇女，其中180名HBsAg（+）HBeAg（+），714名HBsAg（+）HBeAg（-），7名，656例HBsAg阴性对照接受首次IVF治疗。干预：通过Kruskal-Wallis检验、方差分析或卡方检验分析临床特征、妊娠和新生儿结局。Logistic回归分析验证了产妇HBV对临床妊娠、活产和流产的贡献。主要结局指标：主要结局：活产率;次要结局：着床率、临床妊娠率和流产率。结果：HBV患者不孕持续时间延长，继发不孕和排卵障碍增多。与对照组相比，HBsAg（+）HBeAg（-）组的着床率在统计学上显著降低。然而，临床妊娠率、流产率、活产率、新生儿结局和妊娠并发症在各组之间无统计学显著差异。Logistic回归分析显示，HBV感染状态不影响临床妊娠率、流产率或活产率，而与母亲年龄、子宫内膜厚度和使用高质量胚胎不同。B型肝炎病毒感染不是妊娠结局的独立因素，尽管它与不孕持续时间延长、继发性不孕和排卵障碍的发生率高有关，和降低的植入率。((C)2019年由美国生殖医学学会（American Society for Reproductive Medicine）
Objective: To evaluate whether maternal chronic hepatitis B virus (HBV) infection affects pregnancy outcomes in infertile patients undergoing their first in vitro fertilization (IVF) treatment.Design: A retrospective case control study.Setting: Fertility center.Patient(s): Female patients, comprising 8,550 infertile women including 180 HBsAg(+)HBeAg(+), 714 HBsAg(+)HBeAg(-), and 7,656 HBsAg seronegative controls undergoing their first IVF treatments.Intervention(s): Clinical characteristics, pregnancy and neonatal outcomes were analyzed by Kruskal-Wallis test, analysis of variance, or chi-square test. Logistic regression was employed to verify the contribution of maternal HBV to clinical pregnancy, live birth, and miscarriage.Main Outcome Measure(s): Primary outcome: live-birth rate; secondary outcomes: implantation, clinical pregnancy, and miscarriage rates.Result(s): An increased duration of infertility and more secondary infertility and ovulatory disorders were observed in the HBV patients. The implantation rate was statistically significantly lower in the HBsAg(+)HBeAg(-) group compared with the controls. However, the clinical pregnancy rate, miscarriage rate, live-birth rate, neonatal outcomes, and pregnancy complications showed no statistically significant differences among the groups. The logistic regression analysis showed that HBV infection status did not affect the clinical pregnancy, miscarriage, or live-birth rates, unlike maternal age, endometrial thickness, and use of high-quality embryos.Conclusion(s): Hepatitis B virus infection is not an independent contributor to pregnancy outcomes, although it is associated with prolonged infertility duration, a high frequency of secondary infertility and ovulatory disorders, and a reduced implantation rate. ((C) 2019 by American Society for Reproductive Medicine.)