Hexagonal Lyotropic Liquid Crystal from Simple "Abiotic" Foldamers.
Hexagonal Lyotropic Liquid Crystal from Simple "Abiotic" Foldamers.
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来自简单“非生物”折叠器的六方溶致液晶
DOI：
10.1002/open.201600007
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发表时间：
2016-08
期刊：
影响因子：
2.3
通讯作者：
Gao L
中科院分区：
文献类型：
--
作者：
Chen Y;Zhao Z;Bian Z;Jin R;Kang C;Qiu X;Guo H;Du Z;Gao L
折叠体化学的动机是识别具有模仿天然物种潜力的新型结构单元。肽和肽模拟物可以形成稳定的螺旋构象，并在水中进一步自组装成不同的聚集体，其中难以分离单个螺旋。相反，大多数“非生物”折叠体在溶液中可以折叠成螺旋结构，但难以组装成三级结构。获得类似于肽的“非生物”物种仍然是一个挑战。本文设计并制备了一种新型的折叠分子支架，其中对苯撑乙炔基单元通过手性碳原子连接。在非常稀的溶液中，这些低聚物是无规卷曲的。当浓度达到临界值时，六聚体和八聚体在CH_2Cl_2中可形成六方溶致液晶。显微镜观察表明，它们可以组装成纳米纤维的LC。有趣的是，在一些LC相在室温下稀释后，纳米纤维可以被保留。组装体的良好稳定性可能归因于更紧凑的主链和更刚性的侧链。
The motivation of foldamer chemistry is to identify novel building blocks that have the potential to imitate natural species. Peptides and peptide mimetics can form stable helical conformations and further self‐assemble into diverse aggregates in water, where it is difficult to isolate a single helix. In contrast, most “abiotic” foldamers may fold into helical structures in solution, but are difficult to assemble into tertiary ones. It remains a challenge to obtain “abiotic” species similar to peptides. In this paper, a novel foldamer scaffold, in which p‐phenyleneethynylene units are linked by chiral carbon atoms, was designed and prepared. In very dilute solutions, these oligomers were random coils. The hexamer and octamers could form a hexagonal lyotropic liquid crystal (LC) in CH2Cl2 when the concentrations reached the critical values. The microscopic observations indicated that they could assemble into the nanofibers in the LC. Interestingly, after some LC phases were diluted at room temperature, the nanofibers could be preserved. The good stabilities of the assemblies are possibly attributed to a more compact backbone and more rigid side chains.