Crossed unilateral lesions of medial forebrain bundle and either inferior temporal or frontal cortex impair object recognition memory in Rhesus monkeys
Crossed unilateral lesions of medial forebrain bundle and either inferior temporal or frontal cortex impair object recognition memory in Rhesus monkeys
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DOI：
10.1016/s0166-4328(00)00384-3
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发表时间：
2001-06-01
影响因子：
2.7
通讯作者：
Gaffan, D
中科院分区：
文献类型：
--
作者：
Easton, A;Parker, A;Gaffan, D
在猴子中，穹窿、杏仁核和前颞干的切除会导致严重的顺行性遗忘症。基底前脑胆碱能细胞的免疫损伤表明，这种遗忘症是下颞叶皮层和内侧颞叶与其胆碱能基底前脑传入神经隔离的结果。在这个实验中。六只猴子接受了延迟匹配样本任务的训练，然后在一个半球接受了内侧前脑束的一部分，并在另一半球切除了额叶或下颞叶皮层。手术后，所有动物在执行这项任务时都受到严重损害，并且损害的严重程度与内侧前脑束断开的皮质区域无关。这些结果支持新学习中通过基底前脑进行额颞叶相互作用的模型，其中与奖励相关的中脑位点调节胆碱能基底前脑活动。 (C) 2001 Elsevier Science B.V. 保留所有权利。
In monkeys, section of the fornix, amygdala and anterior temporal stem results in a severe anterograde amnesia. Immunolesions of the cholinergic cells of the basal forebrain suggest that this amnesia is a result of isolating the inferior temporal cortex and medial temporal lobe from their cholinergic basal forebrain afferents. In this experiment. six monkeys were trained in a delayed match-to-sample task and then received a section of the medial forebrain bundle in one hemisphere and an ablation of either the frontal or inferior temporal cortex in the opposite hemisphere. All the animals were severely impaired in the performance of this task following this surgery, and the severity of the impairment was independent of the cortical area from which the medial forebrain bundle was disconnected. These results support a model of fronto-temporal interaction via the basal forebrain in new learning, in which midbrain sites related to reward modulate the cholinergic basal forebrain activity. (C) 2001 Elsevier Science B.V. All rights reserved.