Galanin attenuates basal and antidepressant drug-induced increase of extracellular serotonin and noradrenaline levels in the rat hippocampus
Galanin attenuates basal and antidepressant drug-induced increase of extracellular serotonin and noradrenaline levels in the rat hippocampus
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DOI：
10.1016/s0304-3940(03)00020-x
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发表时间：
2003-03-27
影响因子：
2.5
通讯作者：
Kehr, J
中科院分区：
文献类型：
--
作者：
Yoshitake, T;Reenilä, K;Kehr, J
甘丙肽与经典神经递质如乙酰胆碱、5-羟色胺（5-HT）和去甲肾上腺素（NA）共定位于神经元或涉及认知和情感行为的脑区域中。在本研究中，甘丙肽对细胞外5-HT和NA水平在大鼠海马的影响进行了测量在基础条件下，在体内微透析和抗抑郁药物的全身给药。甘丙肽（1.5 nmol i. c. v.）基础5-HT和NA水平分别降低至对照组的65%和86%。甘丙肽（0.5和1.5 nmol i. c. v.）剂量依赖性地减弱了由丙咪嗪和西酞普兰（10 mg/kgi. p.，每种）分别从350%至312%和从230%至160%。1.5 nmol甘丙肽短暂减弱地昔帕明诱导的（10 mg/kg i. p.）细胞外NA水平从前药水平的389-296%的最大增加增加。它的结论是，脑室注射甘丙肽衰减基础5-HT和NA的释放和抗抑郁药物诱导的积累细胞外5-HT和NA水平最有可能通过一个主要的抑制作用，对肾上腺素能和去甲肾上腺素能神经元中缝和蓝斑，分别。这些结果进一步强调了甘丙肽在抑郁状态下和抗抑郁治疗过程中调节5-HT和NA神经传递的可能作用。(C)2003年由Elsevier Science爱尔兰有限公司出版。
Galanin is co-localized with classical neurotransmitters, such as acetylcholine, serotonin (5-HT) and noradrenaline (NA) in neurons or in brain regions implicated in cognitive and affective behaviour. In the present study, the effects of galanin on extracellular 5-HT and NA levels in the rat hippocampus were measured by in vivo microdialysis under basal conditions and following systemic administration of antidepressant drugs. Galanin (1.5 nmol i.c.v.) reduced basal 5-HT and NA levels to 65% and 86% of controls, respectively. Galanin (0.5 and 1.5 nmol i.c.v.) dose-dependently attenuated the elevation of 5-HT concentrations induced by imipramine and citalopram (10 mg/kg i.p., each) from 350% to 312% and from 230% to 160%, respectively. Galanin at 1.5 nmol transiently attenuated the effect of desipramine-induced (10 mg/kg i.p.) increase in extracellular NA levels from a maximal increase of 389-296% of the predrug levels. It is concluded that intraventricularly administered galanin attenuated both basal 5-HT and NA release and antidepressant drug-induced accumulation of extracellular 5-HT and NA levels most likely via a predominant inhibitory action on serotonergic and noradrenergic neurons in the raphe and locus coeruleus, respectively. These results further emphasize a possible role of galanin in regulation of 5-HT and NA neurotransmission in depressive states and during the course of antidepressant therapy. (C) 2003 Published by Elsevier Science Ireland Ltd.