Significant association of the tumor necrosis factor receptor 2 (TNFR2) gene with human narcolepsy
Significant association of the tumor necrosis factor receptor 2 (TNFR2) gene with human narcolepsy
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DOI：
10.1034/j.1399-0039.2000.560508.x
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发表时间：
2000-11-01
期刊：
影响因子：
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通讯作者：
Tokunaga, K
中科院分区：
文献类型：
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作者：
Hohjoh, H;Terada, N;Tokunaga, K
我们报道肿瘤坏死因子受体2 （TNFR2）基因与人类嗜睡症的相关性研究。TNFR2的单核苷酸多态性。它参与了196位的氨基酸取代[蛋氨酸(M)/精氨酸(R)]。以149名日本发作性睡病患者和204名健康人作为对照。结果显示，与对照组相比，患者中TNFR2-196R等位基因的频率显著增加（P=0.029）。提示TNFR2可能与易感性相关；嗜睡症。此外，对TNFR2和TNF α与发作性睡病易感性关系的分析表明，TNFR2- 196r和TNF α -857T等位基因之间可能存在累加效应。
We report on the association study of the tumor necrosis factor receptor 2 (TNFR2) gene with human narcolepsy. A single-nucleotide polymorphism in TNFR2. which is involved in an amino acid substitution [methionine(M)/arginine(R)] at position 196. was investigated in 149 Japanese narcoleptic patients and 204 healthy individuals as controls. Results reveal that the frequency of the TNFR2-196R allele significantly increased in the patients as compared with that in the controls (P=0.029). suggesting that TNFR2 is likely associated with the susceptibility; to narcolepsy. In addition, the analyses of the relationship of TNFR2 and TNF alpha with the susceptibility to narcolepsy indicate the possibility that an additive effect on the susceptibility to the disorder lies between TNFR2-196R and TNF-alpha -857T) alleles.