Characteristics of pregnancy complications and treatment in obstetric antiphospholipid syndrome in China
Characteristics of pregnancy complications and treatment in obstetric antiphospholipid syndrome in China
复制标题
我国产科抗磷脂综合征妊娠并发症的特点及治疗
DOI：
10.1007/s10067-019-04670-7
复制
发表时间：
2019-07
影响因子：
3.4
通讯作者：
Ye Junna
中科院分区：
文献类型：
--
作者：
Zhou Zhuochao;Teng Jialin;Sun Yue;Liu Honglei;Cheng Xiaobing;Su Yutong;Yang Chengde;Ye Junna
抗磷脂综合征（APS）是一种自身免疫性疾病，其特征是与抗磷脂抗体相关的产科并发症和血小板事件（APL）。我们旨在比较主要AP的临床特征和治疗（PAPS）
ObjectivesAntiphospholipid syndrome (APS) is an autoimmune disease characterized by obstetric complications and thrombotic events associated with antiphospholipid antibodies (aPL). We aimed to compare the clinical characteristics and treatment of primary APS (PAPS) and secondary APS (systemic lupus erythematosus-APS, SAPS) patients and investigate risk factors associated with obstetric complications in Shanghai, China.MethodsWe retrospectively collected and analyzed the data of obstetric APS (OAPS) patients from 2000 to 2017 in the APS-Shanghai (APS-SH) database.ResultsOne hundred eighty OAPS patients with a total of 450 pregnancies were included in this study. Two hundred twenty-one (49.11%) pregnancies resulted in miscarriage, and 161 (35.77%) pregnancies resulted in intrauterine death. In our cohort, when women were treated, 57 out of 66 pregnancies resulted in live births (86%). Of the 9 treated patients who failed to have live births, 3 had intrauterine deaths, 3 had fetal growth restriction, 2 had pneumorrhagia of the newborn, and 1 had a miscarriage. OAPS patients were divided into two groups: PAPS and SAPS. More SAPS patients than PAPS patients used glucocorticoids (GCs) and hydroxychloroquine (bothp< 0.001). However, there was no significant difference in the GC dosage between SAPS and PAPS patients (p= 0.188). Lupus anticoagulant (LAC) and IgG aβ2GPI were risk factors for miscarriage (odds ratio (OR) = 2.398, 95% confidence interval (CI) = 1.276–4.505,p= 0.002; OR = 2.907, 95% CI = 1.558–5.405,p= 0.001, respectively) and intrauterine death (OR = 2.439, 95% CI = 1.299–4.580,p= 0.006; OR = 2.060, 95% CI = 1.089–3.897,p= 0.026, respectively).ConclusionsThe live birth rate of OAPS patients in Shanghai was 86%. Even if OAPS patients were treated, pregnancy complications could occur, and these patients might need further second-line treatment.Key Points•This is the first study to report data on Chinese OAPS patients. The live birth rate was 86%.• Lupus anticoagulant and IgG aβ2GPI were risk factors for miscarriage and intrauterine death in our cohort.• Despite active treatment, 9 patients had obstetric complications. Therefore, further second-line treatment is still needed.
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影响因子：
2.6
作者：
Hughes, GRV
通讯作者：
Hughes, GRV
影响因子：
6.7
作者：
Ruffatti, Amelia;Tonello, Marta;Khamashta, Munther A.
通讯作者：
Khamashta, Munther A.
DOI：
10.1182/asheducation-2013.1.675
发表时间：
2013-12-01
影响因子：
3
作者：
Lim, Wendy
通讯作者：
Lim, Wendy
影响因子：
6.7
作者：
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通讯作者：
Meroni, Pier Luigi
影响因子：
10.4
作者：
T. Marchetti;P. Moerloose;Jean-Christophe Gris
通讯作者：
T. Marchetti;P. Moerloose;Jean-Christophe Gris