Intraventricular insulin suppresses the acoustic startle response in rats.
Intraventricular insulin suppresses the acoustic startle response in rats.
复制标题
脑室内注射胰岛素可抑制大鼠的听觉惊吓反应。
DOI：
10.1016/s0031-9384(99)00260-7
复制
发表时间：
2000
影响因子：
2.9
通讯作者：
Figlewicz,DP
中科院分区：
文献类型：
--
作者：
Thompson,SC;Woods,SC;Hendricks,S;Bell,SM;Figlewicz,DP
我们和其他人之前已经报道过，胰岛素在突触和分子水平上改变了大脑去甲肾上腺素的功能。在本研究中，我们研究了胰岛素(通过渗透压小泵以每天5mU的剂量长期注入第三脑室)对声学惊厥反应的体内影响。接受慢性脑室内胰岛素治疗的大鼠的惊吓反应明显低于对照组(即基线对照的47±21%)。由于我们以前的发现表明，在急性基础上，胰岛素可能通过抑制去甲肾上腺素再摄取来增强内源性去甲肾上腺素能活性，我们推测胰岛素的慢性效应类似于去甲肾上腺素再摄取阻滞剂地昔帕明，据报道，地塞帕明可降低基线惊厥表现。
We and others have previously reported that the hormone insulin alters brain noradrenergic function at the synaptic and molecular levels. In the present study, we examined the in vivo effect of insulin (administered chronically via osmotic minipumps at a dose of 5 mU/day into the third cerebral ventricle) on the acoustic startle response. Rats receiving chronic intraventricular insulin had a significantly reduced startle response relative to vehicle-treated controls (i.e., 47 ± 21% of baseline control startle response). Because our previous findings suggest that on an acute basis, insulin may enhance endogenous noradrenergic activity by inhibiting norepinephrine reuptake, we speculate here that the chronic effect of insulin is similar to that of the noradrenergic reuptake blocker, desipramine, which has been reported to decrease baseline startle performance.