Loudness dependence of auditory evoked potentials (LDAEP) in clinical monitoring of suicidal patients with major depression in comparison with non-suicidal depressed patients and healthy volunteers: A follow-up-study
Loudness dependence of auditory evoked potentials (LDAEP) in clinical monitoring of suicidal patients with major depression in comparison with non-suicidal depressed patients and healthy volunteers: A follow-up-study
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DOI：
10.1016/j.jad.2015.06.007
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发表时间：
2015-09-15
影响因子：
6.6
通讯作者：
Uhl, Idun
中科院分区：
文献类型：
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作者：
Grassnickel, Vanessa;Illes, Franciska;Uhl, Idun
由于情感障碍和自杀等特殊情况引起的中枢5-羟色胺能功能的差异可以通过听觉诱发电位(LDAEP)的响度依赖性来可视化。本研究纳入20例重度抑郁发作患者(平均年龄4325±10.85岁，年龄20~61岁，男性11例)，均为汉密尔顿抑郁量表第3项(自杀倾向)所反映的急性自杀未遂或有自杀计划和行为的患者。此外，我们打算将他们的LDAEP与非自杀抑郁症患者以及健康志愿者的LDAEP进行比较，每个志愿者都根据年龄和性别匹配。LDAEP测量和心理测量休息发生在急性自杀行为或自杀未遂后约2、5、9、16和30天。与以前的结果相反，在自杀组之间，或者通过比较自杀患者和非自杀抑郁症患者或健康志愿者的结果，LDAEP不可能显示出显著的差异。然而，当将非自杀抑郁症患者的LDAEP与健康志愿者进行比较时，健康志愿者的LDAEP有升高的趋势。需要进一步的研究来检测和描述对5-羟色胺能功能的进一步影响和混杂因素，如药物、吸烟、年龄、性别、合并症和自杀未遂的方法。(C)2015爱思唯尔B.V.保留所有权利。
Differences in central serotonergic function due to affective disorders and due to extraordinary situations like suicidality may be visualized using the loudness dependence of auditory evoked potentials (LDAEP). Twenty patients (mean age 4325 +/- 10.85, age range 20-61, 11 male) suffering from a major depressive episode who had either acutely attempted suicide or who had suicidal plans and behavior, which are reflected by item 3 of Hamilton Depression Rating Scale >= 3 (suicidality), were included in the study. Furthermore, we intended to compare their LDAEP to those of non-suicidal depressed patients as well as to healthy volunteers, each matched according to age and gender. LDAEP measurement and psychometric rests took place about 2, 5, 9, 16 and 30 days after acute suicidal action or suicide attempts. In contrast to previous results, significant differences in LDAEP could not have been shown in between the suicidal group, or by comparing results of suicidal patients to non-suicidal depressed patients or to healthy volunteers. However, when he LDAEP of non-suicidal depressed patients were compared to healthy volunteers, there was a trend for a higher LDAEP in the healthy volunteers. Further studies are necessary to detect and describe further influences on serotonergic function and confounding factors like medication, smoking, age, gender, comorbidities and methods of suicidal attempts. (c) 2015 Elsevier B.V. All rights reserved.