Evidence for presence of Ig64 anti-immunoglobulin autoantibodies in all human beings
Evidence for presence of Ig64 anti-immunoglobulin autoantibodies in all human beings
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DOI：
10.1016/s0140-6736(00)02223-6
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发表时间：
2000-05-06
期刊：
影响因子：
168.9
通讯作者：
Kirchner, H
中科院分区：
文献类型：
--
作者：
Hennig, C;Rink, L;Kirchner, H
IgG 4抗IgG自身抗体被发现存在于一组健康人的所有血清样本中; IgG 4抗IgA和抗IgE分别仅存在于218个样本中的13个（6%）和218个样本中的8个（3.5%）。这些抗体还显示出对动物免疫球蛋白的亲和力。我们认为，IgG 4抗IgA抗体（最强的发现嗜异性免疫球蛋白）是负责与商业ELISA系统获得的大多数文物。
IgG4 anti-IgG autoantibodies were found to be present in all serum samples from a group of healthy people; IgG4 anti-IgA and anti-IgE were present in only 13 of 218 (6%) and 8 of 218 (3.5%) samples, respectively. These antibodies also showed affinities towards animal immunoglobulins. We suggest that IgG4 anti-IgA antibodies (the strongest found heterophilic immunoglobulins) are responsible for most artifacts obtained with commercial ELISA systems.