SEQUELAE OF LATERAL OVARIAN TRANSPOSITION IN UNIRRADIATED CERVICAL-CANCER PATIENTS
SEQUELAE OF LATERAL OVARIAN TRANSPOSITION IN UNIRRADIATED CERVICAL-CANCER PATIENTS
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DOI：
10.1016/0090-8258(90)90424-j
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发表时间：
1990-11-01
影响因子：
4.7
通讯作者：
SCHWARTZ, PE
中科院分区：
文献类型：
--
作者：
CHAMBERS, SK;CHAMBERS, JT;SCHWARTZ, PE
子宫颈癌患者子宫颈侧位移位（LOT）的后遗症仅在盆腔放射治疗对卵巢保留的影响方面进行了研究。在没有放射治疗的情况下，卵巢功能的保护尚未得到检查，并且在放射或未放射的宫颈癌患者中，需要后续手术的异位卵巢中的症状性卵巢囊肿形成尚未得到解决。我们研究了1978年至1988年期间84例绝经前FIGO IA或IB期宫颈癌患者接受原发性根治性子宫切除术。这些患者均未接受辅助放射治疗。84例患者中有59例接受了根治性子宫切除术（RH），未行LOT。将这些患者与84例除RH外还有LOT的患者中的25例进行比较。有症状的卵巢囊肿的发生率，大多数需要手术干预，在卵巢移位患者中为24%，而在单纯RH患者中为7.4%。 异位卵巢中有症状的良性卵巢蛋白囊肿形成增加了3倍，这是显著的（P = 0.048）。另一方面，在这些RH患者中，LOT似乎并不增加早期绝经的发生率（P > 0.05）。随访时，未接受额外手术或放疗的患者中，4.3%绝经，而仅接受RH的患者中，4.1%绝经，两组患者的平均年龄相当。
The sequelae of lateral transposition (LOT) in cervical cancer patients has been examined only in the light of the effect of pelvic radiation therapy on ovarian preservation. Preservation of ovarian function has not been examined in the absence of radiation therapy, and symptomatic ovarian cyst formation in tranposed ovaries with the need for subsequent surgery has not been addressed in either radiated or unirradiated cervical cancer patients. We studied 84 premenopausal FIGO stage IA or IB cervical cancer patients treated by primary radical hysterectomy between the years 1978 and 1988. None of these patients received adjuvant radiation therapy. Fifty-nine of eight-four patients had radical hysterectomy (RH) without LOT. These patients were compared to 25 of 84 patients who had LOT in addition to RH. The incidence of symptomatic ovarian cysts, the majority requiring operative intervention, was 24% in the ovarian transposition patients as compared to 7.4% in those who had RH alone. This threefold increase in symptomatic benign ovarin cyst formation in the translocated ovary was significant (P = .048). On the other hand, LOT in these RH patients does not appear to increase the incidence of early menopause (P > 0.05). On follow-up of those patients who did not incur additional surgery or radiation, 4.3% became menopausal, as compared to 4.1% of those patients undergoing RH alone, with the mean ages of the two groups being comparable.