RelateAdmix: a software tool for estimating relatedness between admixed individuals
RelateAdmix: a software tool for estimating relatedness between admixed individuals
复制标题
DOI：
10.1093/bioinformatics/btt652
复制
发表时间：
2014-04-01
期刊：
影响因子：
5.8
通讯作者：
Albrechtsen, Anders
中科院分区：
文献类型：
--
作者：
Moltke, Ida;Albrechtsen, Anders
动机：成对相关性在一系列遗传研究领域中起着重要作用。然而，目前只有少数估计存在的个人混合，即有祖先从一个以上的人口，这些估计失败，在某些situations.Results：我们提出了一个新的软件工具，RelateAdmix，获得最大似然估计的成对相关性混合个体之间的遗传数据。我们使用模拟数据表明，它比三种最先进的软件工具，REAP，KING和Plink产生更好的估计，同时仍然足够快，适用于大型数据集。
Motivation: Pairwise relatedness plays an important role in a range of genetic research fields. However, currently only few estimators exist for individuals that are admixed, i.e. have ancestry from more than one population, and these estimators fail in some situations.Results: We present a new software tool, RelateAdmix, for obtaining maximum likelihood estimates of pairwise relatedness from genetic data between admixed individuals. We show using simulated data that it gives rise to better estimates than three state-of-the-art software tools, REAP, KING and Plink, while still being fast enough to be applicable to large datasets.