Ultrashort Echo Time MR Imaging of Osteochondral Junction of the Knee at 3 T: Identification of Anatomic Structures Contributing to Signal Intensity
Ultrashort Echo Time MR Imaging of Osteochondral Junction of the Knee at 3 T: Identification of Anatomic Structures Contributing to Signal Intensity
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DOI：
10.1148/radiol.09081743
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发表时间：
2010-03-01
期刊：
影响因子：
19.7
通讯作者：
Chung, Christine B.
中科院分区：
文献类型：
--
作者：
Bae, Won C.;Dwek, Jerry R.;Chung, Christine B.
用途：通过使用超短回波时间（TE）（UTE）和常规脉冲序列在3 T下对自然发生和实验制备的人软骨-骨标本中的软骨-骨界面进行成像，以（a）确定信号强度模式的外观和（B）识别对UTE MR图像上的信号强度有贡献的结构。本研究被机构审查委员会豁免，不需要知情同意。使用质子密度加权脂肪抑制（重复时间msec/TE msec，2300/34）、T1加权（700/10）和UTE（300/0.008，6.6，有或没有双反转准备，反转时间1 = 135 msec和反转时间2 = 95 msec）序列对5具尸体（平均年龄，86岁± 4岁）髌骨进行成像。将UTE图像与质子密度加权脂肪抑制和T1加权图像进行比较，并由两名放射科医生进行评估。为了识别UTE图像上的信号源，包括特定组织组合的样本（仅未钙化软骨[UCC]、钙化软骨[CC]和软骨下骨[骨] [CC/骨]、仅骨;以及UCC、CC和骨[UCC/CC/骨]）制备并通过使用UTE序列成像。在UTE MR图像上，所有髌骨切片在骨软骨交界处附近显示高强度线性信号，这在蛋白密度加权脂肪抑制或T1加权图像上不可见。在制备好的标本中，UCC单独、CC/骨和UCC/CC/骨标本在UTE图像上均显示高信号，而骨标本则没有。结论：这些结果表明，人体关节UTE图像上的高信号强度来源于CC和UCC的最深层，没有来自软骨下骨的明确贡献。UTE序列可以提供一种评估骨软骨交界处或附近异常的方法。(C)RSNA，2010年
Purpose: To image cartilage- bone interfaces in naturally occurring and experimentally prepared human cartilage-bone specimens at 3 T by using ultrashort echo time (TE) (UTE) and conventional pulse sequences to (a) determine the appearance of the signal intensity patterns and (b) identify the structures contributing to signal intensity on the UTE MR images.Materials and Methods: This study was exempted by the institutional review board, and informed consent was not required. Five cadaveric ( mean age, 86 years +/- 4) patellae were imaged by using proton density-weighted fat-suppressed ( repetition time msec/TE msec, 2300/34), T1-weighted (700/10), and UTE (300/0.008, 6.6, with or without dual-inversion preparations at inversion time 1 = 135 msec and inversion time 2 = 95 msec) sequences. The UTE images were compared with proton density-weighted fat-suppressed and T1-weighted images and were evaluated by two radiologists. To identify the sources of signal on the UTE images, samples including specific combinations of tissues (uncalcified cartilage [UCC] only, calcified cartilage [CC] and subchondral bone [bone] [CC/bone], bone only; and UCC, CC, and bone [UCC/CC/bone]) were prepared and imaged by using the UTE sequence.Results: On the UTE MR images, all patellar sections exhibited a high-intensity linear signal near the osteochondral junction, which was not visible on protein density-weighted fat-suppressed or T1-weighted images. In some sections, focal regions of thickened or diminished signal intensity were also found. In the prepared samples, UCC only, CC/bone, and UCC/CC/bone samples exhibited high signal intensity on the UTE images, whereas bone-only samples did not.Conclusion: These results show that the high signal intensity on UTE images of human articular joints originates from the CC and the deepest layer of the UCC, without a definite contribution from subchondral bone. UTE sequences may provide a way of evaluating abnormalities at or near the osteochondral junction. (C) RSNA, 2010