CONCORDANCE FOR TYPE-1 (INSULIN-DEPENDENT) AND TYPE-2 (NON-INSULIN-DEPENDENT) DIABETES-MELLITUS IN A POPULATION-BASED COHORT OF TWINS IN FINLAND
CONCORDANCE FOR TYPE-1 (INSULIN-DEPENDENT) AND TYPE-2 (NON-INSULIN-DEPENDENT) DIABETES-MELLITUS IN A POPULATION-BASED COHORT OF TWINS IN FINLAND
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DOI：
10.1007/bf02221682
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发表时间：
1992-11-01
期刊：
影响因子：
8.2
通讯作者：
KESANIEMI, YA
中科院分区：
文献类型：
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作者：
KAPRIO, J;TUOMILEHTO, J;KESANIEMI, YA
我们研究了13,888对芬兰同性双胞胎在全国范围内患糖尿病的累积发病率、符合率和遗传度。这对双胞胎出生于1958年之前，同卵双胞胎都活在1967年。关于糖尿病的数据是通过死亡证明、国家医院出院登记簿和国家药物登记簿的计算机化记录链接获得的。为了将诊断类别分配给738名确诊的糖尿病患者，对记录进行了审查。在这些患者中，有109例为1型(胰岛素依赖型)糖尿病，505例为2型(非胰岛素依赖型)糖尿病，46例妊娠期糖尿病，24例继发性糖尿病，38例糖耐量受损，16例仍未分类。28-59岁男性和女性糖尿病累积发病率分别为1.4%和1.3%，60岁及以上男性和女性分别为9.3%和7.0%。同卵双胞胎和异卵双胞胎的累积发病率没有差异。在同卵双胞胎中，1型糖尿病的符合率(23%)高于同卵双胞胎(5%和3%)。在同卵双生子中，2型糖尿病的先验符合率和配对符合率分别为34%和20%，在同卵双胞胎中分别为16%和9%。1型糖尿病的遗传率高于2型糖尿病，后者的遗传和环境影响似乎都起着重要作用。
We studied the cumulative incidence, concordance rate and heritability for diabetes mellitus in a nation-wide cohort of 13,888 Finnish twin pairs of the same sex. The twins were born before 1958 and both co-twins were alive in 1967. Data on diabetes were derived through computerized record linkage from death certificates, the National Hospital Discharge Register and the National Drug Register. Records were reviewed in order to assign a diagnostic category to the 738 diabetic patients identified. Of these patients 109 had Type 1 (insulin-dependent) diabetes, 505 Type 2 (non-insulin-dependent) diabetes, 46 gestational diabetes, 24 secondary diabetes, 38 impaired glucose tolerance and 16 remained unclassified. The cumulative incidence of diabetes was 1.4 % in men and 1.3 % in women aged 28-59 years and 9.3 % and 7.0 % in men and women aged 60 years and over, respectively. The cumulative incidence did not differ between monozygotic and dizygotic twins. The concordance rate for Type 1 diabetes was higher among monozygotic (23 % probandwise and 13 % pairwise) than dizygotic twins (5 % probandwise and 3 % pairwise). The probandwise and pairwise concordance rates for Type 2 diabetes were 34 % and 20 % among monozygotic tiwns and 16 % and 9 % in dizygotic twins, respectively. Heritability for Type 1 diabetes was greater than that for Type 2 where both genetic and environmental effects seemed to play a significant role.