Layered-Crossover Tiles with Precisely Tunable Angles for 2D and 3D DNA Crystal Engineering
Layered-Crossover Tiles with Precisely Tunable Angles for 2D and 3D DNA Crystal Engineering
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DOI：
10.1021/jacs.8b07180
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发表时间：
2018-11-07
影响因子：
15
通讯作者：
Yan, Hao
中科院分区：
文献类型：
--
作者：
Hong, Fan;Jiang, Shuoxing;Yan, Hao
基于DNA瓷砖的组装提供了一条很有前途的自下而上的途径，可以创建设计者的二维(2D)和三维(3D)晶体结构，这些晶体结构可能包含客体分子或纳米颗粒，以实现新的功能。在这里，我们介绍了一种新的DNA瓷砖(称为分层交叉瓷砖)，每个瓷砖由两到四对分层交叉组成，以精确预定的相对方向连接两个相邻层中的DNA螺旋。通过为终端的粘性末端提供适当的匹配规则，这些分层交叉瓷砖能够组装成具有精确控制的角度从20度到80度的2D周期性晶格。这种分层交叉瓷砖可以稍加修改，成功地组装成角度可调的几百微米的3D晶格。这些分层交叉的瓷砖极大地扩展了DNA纳米技术的工具箱，通过自下而上的方法构建材料。
DNA tile-based assembly provides a promising bottom-up avenue to create designer two-dimensional (2D) and three-dimensional (3D) crystalline structures that may host guest molecules or nanoparticles to achieve novel functionalities. Herein, we introduce a new kind of DNA tiles (named layered-crossover tiles) that each consists of two or four pairs of layered crossovers to bridge DNA helices in two neighboring layers with precisely predetermined relative orientations. By providing proper matching rules for the sticky ends at the terminals, these layered-crossover tiles are able to assemble into 2D periodic lattices with precisely controlled angles ranging from 20 degrees to 80 degrees. The layered-crossover tile can be slightly modified and used to successfully assemble 3D lattice with dimensions of several hundred micrometers with tunable angles as well. These layered-crossover tiles significantly expand the toolbox of DNA nanotechnology to construct materials through bottom-up approaches.