Age at onset in bipolar-related major affective illness: clinical and genetic implications.
Age at onset in bipolar-related major affective illness: clinical and genetic implications.
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双相情感障碍相关重大情感疾病的发病年龄：临床和遗传影响。
DOI：
10.1016/0022-3956(82)90030-9
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发表时间：
1982
影响因子：
4.8
通讯作者：
Julien Mendlewicz
中科院分区：
文献类型：
--
作者：
Miron Baron;Neil Risch;Julien Mendlewicz
收集了 142 名双相情感障碍先证者（61 名男性，81 名女性）和 110 名兄弟姐妹的发病年龄数据。校正人口因素后，发病年龄并不能区分双相情感障碍与单相情感障碍兄弟姐妹或兄弟姐妹与先证者。这表明，在谱系数据的子集中，双相情感障碍和单相情感障碍可能是同一潜在疾病的不同表型表现。共有 43% 的受影响者在 30 岁之前提供了患病证据，11% 在青少年时期患病。还有 2% 的人在 15 岁之前受到影响。数据表明，情感疾病在青春期并不罕见，并且可能作为一种儿童疾病出现。通过将人口因素（生存数据）纳入受影响个体发病时观察到的年龄，获得了发病年龄概率分布的估计。平方根正态曲线拟合发病年龄概率密度函数。讨论了情感障碍的发病风险预测和遗传分析的意义。
Age-of-onset data were collected on 142 bipolar probands (61 males, 81 females) and 110 siblings. After correcting for demographic factors the age at illness onset did not distinguish bipolar from unipolar siblings or siblings from probands. This indicates that in a subset of pedigree data, bipolar and unipolar affective disorders may be different phenotypic manifestations of the same underlying disorder. A total of 43% of affected individuals gave evidence of illness before age 30 and 11% were ill as adolescents. Also 2% were affected prior to age 15. The data indicate that affective illness is not uncommon in adolescence and may occur as a childhood disorder. Estimation of the age-of-onset probability distribution was obtained by incorporating demographic factors (survivorship data) into the observed ages at onset of affected individuals. A square-root normal curve fits the age-of-onset probability density function. The implications for morbid risk prediction and genetic analysis of affective disorders were discussed.