Laser induced surface acoustic wave combined with phase sensitive optical coherence tomography for superficial tissue characterization: a solution for practical application
Laser induced surface acoustic wave combined with phase sensitive optical coherence tomography for superficial tissue characterization: a solution for practical application
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DOI：
10.1364/boe.5.001403
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发表时间：
2014-05-01
影响因子：
3.4
通讯作者：
Huang, Zhihong
中科院分区：
文献类型：
--
作者：
Li, Chunhui;Guan, Guangying;Huang, Zhihong
力学性能是评价生物组织生理状态的重要参数。组织机械特性的测量和绘图可以帮助疾病的诊断、表征和治疗。作为一种非侵入、非破坏、非接触的测量方法，激光声表面波（SAW）具有精确测量组织弹性特性的潜力。然而，当激光直接应用于组织时仍然存在挑战，因为激光能量沉积可能产生热量。本文着重研究了激光声表面波对靶组织的热效应，并提出了一种替代方案，以促进其在临床环境中的应用。提出的解决方案是应用薄琼脂膜作为表面屏蔽以保护组织。为了研究高能量Nd：YAG激光脉冲对表面屏蔽层的影响，建立了瞬态热分析方法，并进行了实验验证。然后通过测量Thiel小鼠模型中皮肤的机械性能来验证该方法。实验结果为激光声表面波法测量皮肤病及其它表面上皮组织的真实的弹性迈出了有益的一步。(C)2014年美国光学学会
Mechanical properties are important parameters that can be used to assess the physiologic conditions of biologic tissue. Measurements and mapping of tissue mechanical properties can aid in the diagnosis, characterisation and treatment of diseases. As a non-invasive, non-destructive and non-contact method, laser induced surface acoustic waves (SAWs) have potential to accurately characterise tissue elastic properties. However, challenge still exists when the laser is directly applied to the tissue because of potential heat generation due to laser energy deposition. This paper focuses on the thermal effect of the laser induced SAW on the tissue target and provides an alternate solution to facilitate its application in clinic environment. The solution proposed is to apply a thin agar membrane as surface shield to protect the tissue. Transient thermal analysis is developed and verified by experiments to study the effects of the high energy Nd: YAG laser pulse on the surface shield. The approach is then verified by measuring the mechanical property of skin in a Thiel mouse model. The results demonstrate a useful step toward the practical application of laser induced SAW method for measuring real elasticity of normal and diseased tissues in dermatology and other surface epithelia. (C) 2014 Optical Society of America