Fatal and Nonfatal Events Within 14 days After Early, Intensive Mobilization Poststroke
Fatal and Nonfatal Events Within 14 days After Early, Intensive Mobilization Poststroke
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DOI：
10.1212/wnl.0000000000011106
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发表时间：
2021-02-23
期刊：
影响因子：
9.9
通讯作者：
Donnan, Geoffrey A.
中科院分区：
文献类型：
--
作者：
Bernhardt, Julie;Borschmann, Karen;Donnan, Geoffrey A.
这三级分析从一个非常早期的康复试验（AVERT）检查致命的和非致命的严重不良事件（SAE）在14 days.MethodAVERT是一个前瞻性的，平行组，评估盲，随机国际临床试验比较流动性训练开始80年的亚组，但没有显着的治疗亚组相互作用。在非致命性SAE没有差异被发现。ConclusionWhile在中风后14天的总病死率仅为3.8%，死亡率调整的年龄和中风的严重程度增加与高剂量和强化训练相比，通常的护理。VEM患者的卒中进展更为常见。证据分类本研究提供了I类证据，即极早期活动增加卒中后14天的死亡率。
ObjectiveThis tertiary analysis from A Very Early Rehabilitation Trial (AVERT) examined fatal and nonfatal serious adverse events (SAEs) at 14 days.MethodAVERT was a prospective, parallel group, assessor blinded, randomized international clinical trial comparing mobility training commenced 80 years subgroups, but there was no significant treatment by subgroup interaction. No difference in nonfatal SAEs was found.ConclusionWhile the overall case fatality at 14 days poststroke was only 3.8%, mortality adjusted for age and stroke severity was increased with high dose and intensive training compared to usual care. Stroke progression was more common in VEM.Classification of EvidenceThis study provides Class I evidence that very early mobilization increases mortality at 14 days poststroke.