The Frequency of Tumor-infiltrating Tie-2-expressing Monocytes in Renal Cell Carcinoma: Its Relationship to Angiogenesis and Progression
The Frequency of Tumor-infiltrating Tie-2-expressing Monocytes in Renal Cell Carcinoma: Its Relationship to Angiogenesis and Progression
复制标题
肾细胞癌中肿瘤浸润表达 Tie-2 的单核细胞的频率：其与血管生成和进展的关系
DOI：
10.1016/j.urology.2013.05.026
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发表时间：
2013-10-01
期刊：
影响因子：
2.1
通讯作者：
Hou, Jianquan
中科院分区：
文献类型：
--
作者：
Ji, Jindong;Zhang, Guangbo;Hou, Jianquan
OBJECTIVE To examine the frequency of tumor-infiltrating Tie-2-expressing monocytes (TEMs) in renal cell carcinoma (RCC) and its association with microvessel density (MVD) and other clinical-pathologic features.MATERIALS AND METHODS This study enrolled 65 consecutive patients with RCC treated with radical nephrectomy. The frequency of tumor-infiltrating TEMs, which was defined as CD14(+) Tie-2(+) cells, was assessed using flow cytometry. MVD was measured by immunohistochemistry using anti-CD34 antibody. The association between clinicopathologic parameters, MVD, and the frequency of tumor-infiltrating TEMs in RCC was assessed.RESULTS High frequency of tumor-infiltrating TEMs was significantly associated with advanced stage (P = .018), positive lymph nodes (P = .013), high grade (P = .019), and metastases (P = .006). Correlation analysis revealed that the frequency of TEMs was positively correlated with MVD.CONCLUSION Our findings revealed a significant association between prognostic tumor features, MVD, and the frequency of tumor-infiltrating TEMs in RCC and indicated that TEMs may play an important role in angiogenesis and progression of RCC. (C) 2013 Elsevier Inc.
