Dysregulation of the hypothalamic-pituitary-gonadal axis in experimental autoimmune encephalomyelitis and multiple sclerosis
Dysregulation of the hypothalamic-pituitary-gonadal axis in experimental autoimmune encephalomyelitis and multiple sclerosis
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DOI：
10.1016/s0165-5728(03)00177-2
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发表时间：
2003-07-01
影响因子：
3.3
通讯作者：
Bebo, BF
中科院分区：
文献类型：
--
作者：
Foster, SC;Daniels, C;Bebo, BF
性激素调节细胞因子产生的能力已经确立，但细胞因子调节性激素产生的能力才刚刚开始被研究。我们测量了患有被动实验性自身免疫性脑脊髓炎（EAE）的小鼠和患有性功能障碍的多发性硬化症（MS）患者的性激素。EAE雄性小鼠和MS男性患者血清睾酮水平异常低，而EAE雌性小鼠血清雌激素水平正常。EAE雄性小鼠的细胞因子和睾酮水平呈反比关系，加上血清黄体生成素（LH）水平的增加，表明炎症细胞因子通过直接作用于睾丸间质细胞来抑制睾酮的产生。下丘脑-垂体-性腺（HPG）轴对炎症敏感性的性别差异可能是调节中枢神经系统（CNS）自身免疫持续时间和严重程度的重要因素。(C) 2003 Elsevier B.V.版权所有
The ability of sex hormones to regulate cytokine production is well established, but the ability of cytokines to regulate sex hormone production has only begun to be investigated. We measured sex hormones in mice with passive experimental autoimmune encephalomyelitis (EAE) and in multiple sclerosis (MS) patients with sexual dysfunction. Abnormally low serum testosterone levels were found in male mice with EAE and in male MS patients, while serum estrogen levels in female mice with EAE were normal. An inverse relationship between cytokine and testosterone levels in male mice with EAE, coupled with an increase in serum luteinizing hormone (LH) levels, suggests that inflammatory cytokines suppress testosterone production by a direct effect on testicular Leydig cells. Gender differences in the sensitivity of the hypothalamic-pituitary-gonadal (HPG) axis to inflammation may be an important factor regulating the duration and severity of central nervous system (CNS) autoimmunity. (C) 2003 Elsevier B.V. All rights reserved.