Forward Processing of Object-Location Association from the Ventral Stream to Medial Temporal Lobe in Nonhuman Primates
Forward Processing of Object-Location Association from the Ventral Stream to Medial Temporal Lobe in Nonhuman Primates
复制标题
非人类灵长类动物从腹侧流到内侧颞叶的对象位置关联的前向处理
DOI：
10.1093/cercor/bhz164
复制
发表时间：
2020-03-01
期刊：
影响因子：
3.7
通讯作者：
Naya, Yuji
中科院分区：
文献类型：
--
作者：
Chen, He;Naya, Yuji
尽管海马（HPC）是将物体身份和位置结合的主要候选者，因为它通过周围的颞叶（MTL）区域与腹侧和背侧途径有牢固的联系，但最近的生理研究报告了腹侧途径的空间信息及其在MTL中的下游目标。但是，尚不清楚对象位置关联是否在HPC之前沿着腹侧MTL途径进行。为了解决这个问题，我们记录了两个猕猴凝视一个对象的MTL和区域前稳态皮层（TE）的神经元活动，以在每个试验中保留其身份和位置。结果表明，在TE，Perirhinal Cortex（PRC）和HPC中，对象位置关联在单单位水平上的显着影响，但在Parahippocampal Cortex中却没有。值得注意的是，关联形式出现了明显的区域差异：1）对象标识的表示形式被添加到受试者在TE中的查看位置的表示； 2）PRC向两个输入的添加形式和连词发出信号； 3）HPC仅信号信号。这些结果表明，每次灵长类动物查看对象时，将对象和位置信号在TE和PRC上逐步合并，并且PRC可以为HPC提供连接信号，该信号可用于编码情节内存。
While the hippocampus (HPC) is a prime candidate combining object identity and location due to its strong connections to the ventral and dorsal pathways via surrounding medial temporal lobe (MTL) areas, recent physiological studies have reported spatial information in the ventral pathway and its downstream target in MTL. However, it remains unknown whether the object-location association proceeds along the ventral MTL pathway before HPC. To address this question, we recorded neuronal activity from MTL and area anterior inferotemporal cortex (TE) of two macaques gazing at an object to retain its identity and location in each trial. The results showed significant effects of object-location association at a single-unit level in TE, perirhinal cortex (PRC), and HPC, but not in the parahippocampal cortex. Notably, a clear area difference emerged in the association form: 1) representations of object identity were added to those of subjects' viewing location in TE; 2) PRC signaled both the additive form and the conjunction of the two inputs; and 3) HPC signaled only the conjunction signal. These results suggest that the object and location signals are combined stepwise at TE and PRC each time primates view an object, and PRC may provide HPC with the conjunctional signal, which might be used for encoding episodic memory.