IgD allotypic determinants. I. Determinants expressed on murine IgD of the a allotype.
IgD allotypic determinants. I. Determinants expressed on murine IgD of the a allotype.
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IgD 同种异型决定因素。
作者：
V. Woods;S. Kessler;F. Finkelman;R. Lieberman;I. Scher;W. Paul
用一系列能与BALB/c脾细胞IgD结合的抗δ试剂测定27株小鼠膜IgD的异体型。其中一种试剂是新定义的异体特异性兔抗小鼠δ a。用这些试剂分型可以揭示先前描述的IgD.36的菌株分布（Ig5.1）和IgD.43（Ig5.4）特异性，并证明存在一种新的特异性IgD.45(Ig5.5)。结果证实了先前将Igh-Ce单倍型细分为A小鼠所归属的Igh-Ce和NZB和NZW小鼠所归属的Igh-Cn。此外，研究表明，high - cd单倍型也必须被细分。在g -5（δ）位点表达a等位基因的AKR小鼠被指定为具有g - cd单倍型，而在g -5（δ）位点表达e等位基因的AL/N和C.AL20小鼠被指定为具有新的g - c单倍型。
Allotypes of membrane IgD of 27 strains of mice were determined with a series of anti-delta reagents, each capable of binding to the IgD of BALB/c spleen cells. One of these reagents is a newly defined allospecific rabbit anti-mouse-delta a. Typing with these reagents reveals the strain distribution of the previously described IgD.36 (Ig5.1) and IgD.43 (Ig5.4) specificities and demonstrates the existence of a new specificity, IgD.45 (Ig5.5). The results confirm the previous subdivision of the Igh-Ce haplotype into Igh-Ce, to which A mice are assigned, and Igh-Cn, to which NZB and NZW mice are assigned. In addition, it is shown that the Igh-Cd haplotype must also be subdivided. AKR mice, which express the a allele at the Igh-5(delta) locus, are designated as possessing the Igh-Cd haplotype while AL/N and C.AL20 mice, which have the e allele at the Igh-5(delta) locus, are assigned a new Igh-C haplotype designation, o.