Covid-19 Risk by work-related factors: Pooled analysis of individual linked data from 14 cohorts
Covid-19 Risk by work-related factors: Pooled analysis of individual linked data from 14 cohorts
复制标题
按工作相关因素划分的 Covid-19 风险：对 14 个队列的个人关联数据进行汇总分析
DOI：
10.1101/2023.12.19.23298502
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Gittins M
中科院分区：
文献类型：
--
作者：
Gittins M
背景SARS-CoV-2感染率因职业而异，但与工作相关特征（如在家工作，关键工作者或休假）的关联尚未完全了解，可能取决于确定方法。我们评估了工作相关特征的感染风险，并使用不同的确认方法比较了结果。Methods 14项英国纵向队列研究的参与者在COVID-19大流行之前和期间完成了关于他们的健康，工作和行为的调查。这些数据在英国纵向联系协作（UK LLC）研究环境中与国家卫生服务数字健康记录（包括COVID-19诊断测试）相关联。Poisson回归模拟了每个队列中自我报告的感染和诊断测试证实的感染的工作相关特征。然后使用随机效应荟萃分析将相对风险（RR）合并。结果在2020年3月至2021年3月期间，74 757人完成了167 302次调查。总的来说，15174份调查答复自我报告感染，而3053份调查答复的检测结果呈阳性。自我报告的感染风险在关键工作者中高于非关键工作者（RR=1.24（95% CI 1.17，1.31）），在非在家工作者（1.08（0.98，1.19））或一些在家工作者（1.06（0.97，1.17））中高于所有在家工作者。兼职工人与全职工人（0.94（0.89，0.99））和休假与不休假（0.93（0.88，0.99））的风险降低。结果相关联的积极测试结果是方向相当，但更大的幅度，例如，1.85（1.56，2.20）在keyworld.ConclusionThe英国有限责任公司提供了新的机会，研究人员调查的风险因素，包括职业因素，在多个大规模的英国队列的健康不良事件。SARS-CoV-2感染和COVID-19疾病的风险似乎与工作相关特征相关。使用关联诊断测试数据的关联似乎比自我报告的感染状态更强。
BackgroundSARS-CoV-2 infection rates vary by occupation, but the association with work-related characteristics (such as home working, keyworker or furlough) are not fully understood and may depend on ascertainment approach. We assessed infection risks across work-related characteristics and compared findings using different ascertainment approaches.MethodsParticipants of 14 UK-based longitudinal cohort studies completed surveys before and during the COVID-19 pandemic about their health, work and behaviour. These data were linked to the National Health Service digital health records, including COVID-19 diagnostic testing, within the UK Longitudinal Linkage Collaboration (UK LLC) research environment. Poisson regression modelled self-reported infection and diagnostic test confirmed infection within each cohort for work-related characteristics. Relative Risk (RR) were then combined using random effects meta-analysis.ResultsBetween March 2020 and March 2021, 74 757 individuals completed 167 302 surveys. Overall, 15 174 survey responses self-reported an infection, whereas 3053 had a linked positive test. Self-reported infection risk was greater in keyworkers versus not (RR=1.24 (95% CI 1.17, 1.31), among non-home working (1.08 (0.98, 1.19)) or some home working (1.06 (0.97, 1.17)) versus all home working. Part-time workers versus full time (0.94 (0.89, 0.99)) and furlough versus not (0.93 (0.88, 0.99)) had reduced risk. Results for the linked positive test outcome were comparable in direction but greater in magnitude, for example, a 1.85 (1.56, 2.20) in keyworkers.ConclusionThe UK LLC provides new opportunities for researchers to investigate risk factors, including occupational factors, for ill-health events in multiple largescale UK cohorts. Risk of SARS-CoV-2 infection and COVID-19 illness appeared to be associated with work-related characteristics. Associations using linked diagnostic test data appeared stronger than self-reported infection status.
影响因子：
4.9
作者：
Nafilyan, Vahe;Pawelek, Piotr;Pearce, Neil
通讯作者：
Pearce, Neil