Adenyl cyclases and cAMP in plant signaling - past and present.
Adenyl cyclases and cAMP in plant signaling - past and present.
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DOI：
10.1186/1478-811x-8-15
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发表时间：
2010-06-25
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影响因子：
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通讯作者：
Gehring C
中科院分区：
文献类型：
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作者：
Gehring C
在低等真核生物和动物中，3 '-5'-环腺苷酸（cAMP）和腺苷酸环化酶（AC），催化ATP形成cAMP的酶，长期以来一直被确定为许多信号通路中的关键组分和第二信使。相比之下，在植物中，cAMP的存在和生物学作用一直是一个持续争论和一些争议的问题。在这里，我们将首先集中在细胞cAMP在植物中的发现和证据，这第二信使在植物信号转导中的作用。其次，我们将审查目前的证据，植物活性炭，分析方面的结构域组织和候选分子的生物学作用。此外，我们将评估不同的方法的基础上搜索基序组成的功能分配的氨基酸在催化中心的注释和/或实验测试的核苷酸环化酶，可以有助于识别新的候选分子与AC活性，如F盒和TIR蛋白。
In lower eukaryotes and animals 3'-5'-cyclic adenosine monophosphate (cAMP) and adenyl cyclases (ACs), enzymes that catalyse the formation of cAMP from ATP, have long been established as key components and second messengers in many signaling pathways. In contrast, in plants, both the presence and biological role of cAMP have been a matter of ongoing debate and some controversy. Here we shall focus firstly on the discovery of cellular cAMP in plants and evidence for a role of this second messenger in plant signal transduction. Secondly, we shall review current evidence of plant ACs, analyse aspects of their domain organisations and the biological roles of candidate molecules. In addition, we shall assess different approaches based on search motifs consisting of functionally assigned amino acids in the catalytic centre of annotated and/or experimentally tested nucleotide cyclases that can contribute to the identification of novel candidate molecules with AC activity such as F-box and TIR proteins.