Magnetic resonance findings in women at high risk for developing breast cancer: An Australian feasibility study
Magnetic resonance findings in women at high risk for developing breast cancer: An Australian feasibility study
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DOI：
10.1111/j.1440-1673.2007.01907.x
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发表时间：
2008-02-01
影响因子：
1.6
通讯作者：
Saunders, C.
中科院分区：
文献类型：
--
作者：
Peters, G.;Anderson, J.;Saunders, C.
在患乳腺癌风险较高的年轻妇女中，乳房X线摄影的价值受到以下因素的限制：乳腺组织密度较高、基因携带者中DCIS的发生率较低、肿瘤生长较快以及对辐射暴露的担忧。我们报告我们的经验，磁共振筛查高风险患者超过三年的时间。患有乳腺癌的高风险妇女除了每年的乳房X光检查外，还接受了MRI扫描和超声波检查，为期两年。采用以下MR方案：增强前T2 STIR序列和增强前3D FLASH序列，增强后轴向动态3D FLASH序列。72名妇女同意参加这项研究。进行了139次乳腺MRI检查。两个癌前病变和腋窝淋巴结转移被发现，但大多数病变是良性的。本文讨论了筛查高危年轻妇女的困难。在我们的研究中，检测到三个显著的病变。两处病变为癌前病变，因此可治愈。召回率显示了筛查年轻乳房的困难性。MRI产生了更多被判断为不确定的结果，因此需要短期随访研究或MR引导活检技术。
In younger women at high risk for developing breast cancer the value of mammography is limited by a higher prevalence of breast tissue density, low rate of DCIS in gene carriers, faster growing tumours and concerns over radiation exposure. We report on our experience of MR screening in high risk patients over a three year period. Women at high risk of developing breast cancer were offered an MRI scan and an Ultrasound in addition to their annual mammogram for two years. The following MR-protocol was used: pre-contrast T2 STIR sequence and pre contrast 3D FLASH sequence, post contrast axial dynamic 3D FLASH sequence. Seventy two women consented to participate in this study. One hundred thirty nine breast MRI examinations were performed. Two pre-cancerous lesions and an axillary lymph node metastasis were found, but the majority of the lesions were benign. Difficulties in screening young women at high risk are discussed in this paper. in our study three lesions of significance were detected. Two lesions were precancerous thus curable. The recall rates show the difficult nature of screening younger breasts. MRI generated more findings judged as uncertain, so short term-term follow up studies or MR-guided biopsy techniques are required.