Palladium-Catalyzed Aerobic Oxidative Cross-Coupling Reactions of Terminal Alkynes with Alkylzinc Reagents
Palladium-Catalyzed Aerobic Oxidative Cross-Coupling Reactions of Terminal Alkynes with Alkylzinc Reagents
复制标题
钯催化末端炔烃与烷基锌试剂的有氧氧化交叉偶联反应
DOI：
10.1021/ja100630p
复制
发表时间：
2010-03-31
影响因子：
15
通讯作者：
Lei, Aiwen
中科院分区：
文献类型：
--
作者：
Chen, Mao;Zheng, Xiaolong;Lei, Aiwen
以空气为氧化剂，在室温下，在Pd催化剂的存在下，末端炔可以与烷基锌试剂直接交叉偶联。发现CO在获得高化学产率和选择性方面是关键的。测试了宽范围的炔和烷基锌试剂，并且获得了良好至优异的产率。
With air as the oxidant, terminal alkynes can be directly cross-coupled with alkylzinc reagents in the presence of a Pd catalyst at room temperature. CO was found to be critical in gaining high chemical yields and selectivities. A wide range of alkynes and alkylzinc reagents were tested, and good to excellent yields were obtained.