Wnt signaling in development and tissue homeostasis
Wnt signaling in development and tissue homeostasis
复制标题
DOI：
10.1242/dev.146589
复制
发表时间：
2018-06-01
期刊：
影响因子：
4.6
通讯作者：
Angers, Stephane
中科院分区：
文献类型：
--
作者：
Steinhart, Zachary;Angers, Stephane
Wnt-β-连环蛋白信号通路是一种进化上保守的细胞-细胞通讯系统，其对于胚胎发生期间和成体组织稳态期间的干细胞更新、细胞增殖和细胞分化都是重要的。导致Wnt-β-连环蛋白信号级联的低活化或高活化的遗传或表观遗传事件也与人类疾病如癌症相关。因此，了解这一途径的功能对于开发治疗疾病的疗法或再生医学方法是不可或缺的。在这里，并在所附的海报，我们提供了一个概述Wnt-β-连环蛋白信号，并简要强调其在发展和成人组织稳态的关键功能。
The Wnt-beta-catenin signaling pathway is an evolutionarily conserved cell-cell communication system that is important for stem cell renewal, cell proliferation and cell differentiation both during embryogenesis and during adult tissue homeostasis. Genetic or epigenetic events leading to hypo-or hyper-activation of the Wnt-beta-catenin signaling cascade have also been associated with human diseases such as cancer. Understanding how this pathway functions is thus integral for developing therapies to treat diseases or for regenerative medicine approaches. Here, and in the accompanying poster, we provide an overview of Wnt-beta-catenin signaling and briefly highlight its key functions during development and adult tissue homeostasis.