EARLY CEREBELLAR LESIONS IMPAIR EYEBLINK CONDITIONING IN DEVELOPING RATS - DIFFERENTIAL-EFFECTS OF UNILATERAL LESIONS ON POSTNATAL DAY-10 OR DAY-20
EARLY CEREBELLAR LESIONS IMPAIR EYEBLINK CONDITIONING IN DEVELOPING RATS - DIFFERENTIAL-EFFECTS OF UNILATERAL LESIONS ON POSTNATAL DAY-10 OR DAY-20
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DOI：
10.1037/0735-7044.109.5.893
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发表时间：
1995-10-01
影响因子：
1.9
通讯作者：
STANTON, ME
中科院分区：
文献类型：
--
作者：
FREEMAN, JH;CARTER, CS;STANTON, ME
实验1证明，同侧小脑半球对于新生大鼠获得眨眼条件反射是必不可少的，出生后第10天给予小脑损伤(PND10)，当给予两侧大脑半球时，小脑损伤会导致眨眼条件反射缺陷。对于两个半球，局限于小脑皮质的损伤比包括深部核团的损伤产生的严重缺陷要轻。实验2表明，小脑损伤发生的年龄决定了对侧小脑半球的损伤是否会损害条件反射。在PND10给药时，包括深核在内的同侧或对侧大脑半球的病变会扰乱眨眼条件反射。相反，当在PND20上进行损害时，包括深核在内的同侧损害取消了条件反射，而给予对侧大脑半球的相同损害没有影响。
Experiment 1 demonstrated that the ipsilateral cerebellar hemisphere is essential for the acquisition of eyeblink conditioning in infant rats and that cerebellar lesions given on Postnatal Day 10 (PND10) produced deficits in eyeblink conditioning when given to either hemisphere. For both hemispheres, lesions that were restricted to the cerebellar cortex produced less severe deficits than lesions that included the deep nuclei. Experiment 2 showed that the age at which the cerebellar lesions occurred determined whether damage to the contralateral cerebellar hemisphere impaired conditioning. Lesions of either the ipsilateral or contralateral hemisphere that included the deep nuclei disrupted eyeblink conditioning when given on PND10. In contrast, when lesions were given on PND20, ipsilateral lesions that included the deep nuclei abolished conditioning, while the same lesion given to the contralateral hemisphere had no effect.