Role of cancer cell-stroma interaction in invasive growth of cancer cells.
Role of cancer cell-stroma interaction in invasive growth of cancer cells.
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DOI：
10.1111/j.1749-0774.2003.tb00123.x
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发表时间：
2003-03-01
期刊：
影响因子：
4.3
通讯作者：
Itoh, Hiroshi
中科院分区：
文献类型：
--
作者：
Kataoka, Hiroaki;Tanaka, Hiroyuki;Itoh, Hiroshi
侵袭性生长是恶性肿瘤的标志之一。迄今为止，大量的证据正在积累，支持侵入性生长是由癌细胞和宿主基质细胞之间的相互作用引起的，所述宿主基质细胞包括成纤维细胞（肌成纤维细胞）、内皮细胞和白细胞，所有这些细胞本身都是侵入性的。在这篇综述中，我们描述了侵袭性癌细胞和宿主间质成纤维细胞之间的串扰和细胞周围微环境对癌细胞侵袭性表型的影响，重点是两种分子，细胞外基质金属蛋白酶诱导剂（EMMPRIN，也称为肿瘤细胞衍生的胶原酶刺激因子，basigin，CD147）和肝细胞生长因子（HGF，也称为散射因子）。这两种分子都深入参与调节侵袭相关的细胞活动，如癌细胞的细胞周蛋白水解、迁移和异位存活。
Invasive growth is one of the hallmarks of cancer malignancy. To date, a significant body of evidence is accumulating in favor of the notion that invasive growth results from the cross-talk between cancer cells and the host stromal cells, comprising fibroblasts (myofibroblasts), endothelial cells, and leukocytes, all of which are themselves invasive. In this review we describe cross-talk between invasive cancer cells and host stromal fibroblasts and an impact of pericellular microenvironment on the invasive phenotype of cancer cells, focusing on two molecules, extracellular matrix metalloproteinase inducer (EMMPRIN, also known as tumor cell-derived collagenase stimulatory factor, basigin, CD147) and hepatocyte growth factor (HGF, also known as scatter factor). Both molecules are deeply involved in the regulation of invasion-associated cellular activities, such as pericellular proteolysis, migration and ectopic survival of cancer cells.