Helicobacter pylori and the t(11;18)(q21;q21) Translocation in Gastric Low‐grade B‐Cell Lymphoma of Mucosa‐associated Lymphoid Tissue Type
Helicobacter pylori and the t(11;18)(q21;q21) Translocation in Gastric Low‐grade B‐Cell Lymphoma of Mucosa‐associated Lymphoid Tissue Type
复制标题
幽门螺杆菌和粘膜相关淋巴组织型胃低级别 B 细胞淋巴瘤中的 t(11;18)(q21;q21) 易位
DOI：
--
复制
发表时间：
2000
期刊：
影响因子：
--
通讯作者：
M. Seto
中科院分区：
文献类型：
--
作者：
Tsuneya Nakamura;S. Nakamura;M. Yonezumi;Takashi Suzuki;A. Matsuura;Y. Yatabe;T. Yokoi;K. Ohashi;M. Seto
据报道，幽门螺杆菌 (H. pylori) 感染治疗后粘膜相关淋巴组织 (MALT) 型胃低级别 B 细胞淋巴瘤的消退尚未得到全面分析，特别是最近发现的由 MALT 淋巴瘤中发现的 t(11;18)(q21;q21) 染色体易位引起的 c-IAP2-MALT1/MLT 基因改变。在 30 名接受抗菌治疗的患者中研究了 MALT 淋巴瘤和幽门螺杆菌之间的关系。通过内窥镜检查和活检对患者进行随访。分子遗传学分析重点关注是否存在由 t(11;18)(q21;q21) 易位导致的免疫球蛋白重链 (IgH) 基因和/或 MALT1/MLT 基因改变。 30 名患者中有 26 名幽门螺杆菌呈阳性。幽门螺杆菌感染的总体治愈率为96%（25/26）。 13 名患者 (52%) 表现出淋巴瘤完全缓解 (CR)，9 名 (36%) 患者部分缓解 (PR)，3 名 (12%) 患者无变化 (NC)。统计分析显示，CR 和 PR/NC 患者在年龄（< 60 或 60 岁）、淋巴瘤部位（单个或多个部位）以及根除前是否存在基因重排方面存在显着差异（P < 0.05）。内窥镜检查仅在 PR 病例中显示鹅卵石外观，而息肉样特征主要在 NC 病例中显示。在 Southern 印迹分析中，两名具有息肉样外观的 NC 患者显示出涉及 c-IAP2 或 MALT1 基因的重排，而其他 7 名具有非息肉样表面外观的切除患者均未显示出重排。根据根除幽门螺杆菌的反应，胃 MALT 淋巴瘤实际上可以分为三组：CR (MALT-A)、PR (MALT-B) 和 NC (MALT-C)。我们推测 MALT-A 可能代表一种早期肿瘤或不典型增生，MALT-B 代表由幽门螺杆菌抗原刺激激活的肿瘤，而 MALT-C 代表独立于幽门螺杆菌的淋巴瘤。 MALT-C 中的息肉样病变与 t(11;18)(q21;q21) 引起的 c-IAP2-MALT1/MLT 基因改变相关。该分类被认为对于决定 MALT 型淋巴增殖性疾病的最合适治疗模式具有临床意义。
The reported regression of mucosa‐associated lymphoid tissue (MALT) type gastric low‐grade Bcell lymphoma following treatment for Helicobacter pylori (H. pylori) infection has not yet been comprehensively analyzed, especially in relation to the recently identified c‐IAP2‐MALT1/MLT gene alteration resulting from the t(11;18)(q21;q21) chromosomal translocation found in MALT lymphoma. The relationship between MALT lymphomas and H. pylori was investigated in 30 patients who received an antibacterial treatment. Patients were followed up by means of endoscopy and biopsy. Molecular genetic analyses focused on the presence or absence of the immunoglobulin heavy chain (IgH) gene and/or MALT1/MLT gene alteration resulting from t(11;18)(q21;q21) translocation. H. pylori was positive in 26 of the 30 patients. The overall success rate of cure of H. pylori infection was 96% (25/26). Thirteen patients (52%) showed complete remission (CR) of lymphoma, nine (36%) partial remission (PR), and three (12%) registered no change (NC). Statistical analysis revealed significant differences between CR and PR/NC patients in age (< 60 or 60), in lymphoma location (single or multiple sites) and in the presence or absence of gene rearrangement before eradication (P< 0.05). Endoscopy showed a cobblestone appearance only in PR cases and polypoid features predominantly in NC cases. Two NC patients with polypoid gross appearance showed rearrangements involving either c‐IAP2 or MALT1 gene in Southern blot analysis, while none of seven other resected patients with non‐polypoid superficial gross appearance showed rearrangement. Gastric MALT lymphoma could be pragmatically subdivided into three groups, CR (MALT‐A), PR (MALT‐B), and NC (MALT‐C) on the basis of the reaction to eradication of H.pylori. We speculate that MALT‐A may represent an incipient neoplasm or dysplasia, MALT‐B a neoplasm activated by antigenic stimulation of H. pylori, and MALT‐C a lymphoma independent of H. pylori. Polypoid lesions in MALT‐C were associated with c‐IAP2‐MALT1/MLT gene alteration resulting from t(11;18)(q21;q21). This classification is thought to be clinically significant for deciding the most appropriate mode of treatment of MALT‐type lymphoproliferative disorders.
影响因子：
158.5
作者：
PARSONNET, J;HANSEN, S;FRIEDMAN, GD
通讯作者：
FRIEDMAN, GD