Advances in magnetofection -: magnetically guided nucleic acid delivery
Advances in magnetofection -: magnetically guided nucleic acid delivery
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DOI：
10.1016/j.jmmm.2005.01.032
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发表时间：
2005-05-01
影响因子：
2.7
通讯作者：
Plank, C
中科院分区：
文献类型：
--
作者：
Schillinger, U;Brill, T;Plank, C
磁转染是通过作用于与磁性纳米颗粒相关联的核酸穿梭物（载体）的磁场的吸引力支持和位点特异性引导核酸递送至细胞。该方法的最新进展证实了其对小型和大型核酸和病毒的普遍适用性。该方法的治疗应用以及机制的研究将被讨论。(c)2005 Elsevier B.V.保留所有权利。
Magnetofection is nucleic acid delivery to cells supported and site-specifically guided by the attractive forces of magnetic fields acting on nucleic acid shuttles (vectors) which are associated with magnetic nanoparticles. Recent progress with the method confirms its general applicability with small and large nucleic acids and viruses. The method's therapeutic application as well as mechanistic studies will be discussed. (c) 2005 Elsevier B.V. All rights reserved.